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Disease Activity Score on 28 Joints and Polypharmacy Are Independent Predictors for Health-Related Quality of Life Evaluated by INCAVISA in Patients With Rheumatoid Arthritis

2016; Lippincott Williams & Wilkins; Volume: 22; Issue: 8 Linguagem: Inglês

10.1097/rhu.0000000000000463

1536-7355

Linda Mariana González-Gamboa, Ana Karen Barocio-Ramírez, Alberto Daniel Rocha-Muñoz, Fabiola de Santos-Ávila, Rosa Martha Meda Lara, Laura González-López, Jorge Iván Gámez-Nava, Eduardo Gómez-Bañuelos, Efraín Chavarría-Ávila, Sergio Durán-Barragán, Rosa Elena Navarro-Hernández, Óscar Pizano-Martínez, Lourdes Núñez-Atahualpa, Mónica Vázquez-Del Mercado,

Autoimmune and Inflammatory Disorders Research

Objective The aim of this study was to investigate the main factors associated to a diminished health-related quality of life (HRQoL) evaluated by INCAVISA (Health-Related Quality of Life Inventory for Latin American Patients) in patients with rheumatoid arthritis (RA). Methods Female, 18 years or older, RA (American College of Rheumatology 1987 criteria and American College of Rheumatology/European League against Rheumatism 2010 criteria) patients who attended the outpatient rheumatology department of the Hospital Civil “Dr. Juan I. Menchaca,” Guadalajara, Mexico, matched with healthy controls were included. Patients with any known comorbidities or treatment with antidepressive drugs were excluded. Trained physicians performed the RA clinical evaluation and INCAVISA. All data were analyzed using SPSS 21.0 software (SPSS Inc, Chicago, IL); P < 0.05 was considered statistically significant. Results Patients with polypharmacy (≥3 drugs) had a lower HRQoL by INCAVISA. The number of drugs, total comorbidities, and DAS-28 (Disease Activity Score on 28 Joints) were negatively correlated with total INCAVISA. In multivariate analysis, DAS-28 and polypharmacy were independent predictors for a negative perception of HRQoL evaluated by INCAVISA in RA patients. Conclusions Disease activity and disability secondary to RA have a negative impact in the HRQoL. Other factors such as the number of drugs prescribed to these patients have been shown to be important for the negative perception of their HRQoL evaluated by INCAVISA.