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Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

2016; American Physical Society; Volume: 312; Issue: 1 Linguagem: Inglês

10.1152/ajpheart.00482.2016

1522-1539

Reggie Hui‐Chao Lee, Alexandre Couto e Silva, F. Lerner, Carl S. Wilkins, Stephen E. Valido, Daniel D. Klein, Celeste Yin‐Chieh Wu, Jake T. Neumann, David Della‐Morte, Stephen H. Koslow, Alireza Minagar, Hung Wen Lin,

Vagus Nerve Stimulation Research

Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism(s) of the sympathetic nervous system during ischemia.Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.