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Prognostic nutritional index as a prognostic biomarker for survival in digestive system carcinomas

2016; Impact Journals LLC; Volume: 7; Issue: 52 Linguagem: Inglês

10.18632/oncotarget.13472

1949-2553

Yang Zhao, Peng Xu, Huafeng Kang, Shuai Lin, Meng Wang, Pengtao Yang, Cong Dai, Xinghan Liu, Kang Liu, Yi Zheng, Zhijun Dai,

Pancreatic and Hepatic Oncology Research

// Yang Zhao 1, * , Peng Xu 1, * , Huafeng Kang 1 , Shuai Lin 1 , Meng Wang 1 , Pengtao Yang 1 , Cong Dai 1 , Xinghan Liu 1 , Kang Liu 1 , Yi Zheng 1 , Zhijun Dai 1 1 Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, PR China * These authors contributed equally to this work and share joint first authorship Correspondence to: Zhijun Dai, email: dzj0911@126.com Keywords: prognostic nutritional index, digestive system carcinomas, prognosis, meta-analysis Received: June 16, 2016 Accepted: November 08, 2016 Published: November 19, 2016 ABSTRACT The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly associated with the shorter overall survival (OS) [Hazard Ratio (HR) 1.83, 95% Confidence Interval (CI) 1.62–2.07], the poorer disease-free survival (DFS) (HR 1.85, 95% CI 1.19–2.89), and the higher rate of post-operative complications (HR 2.31, 95% CI 1.63–3.28). In conclusion, PNI was allowed to function as an efficient indicator for the prognosis of patients with digestive system carcinomas.