Portal de Periódicos da CAPES

Roles of interleukin-17 in uveitis

2016; Medknow; Volume: 64; Issue: 9 Linguagem: Inglês

10.4103/0301-4738.194339

1998-3689

Marta Guedes, Luís Miguel Borrego, Rui Proença,

Systemic Lupus Erythematosus Research

Th17 cells, a CD4+ T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway.