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GlioVis data portal for visualization and analysis of brain tumor expression datasets

2016; Oxford University Press; Volume: 19; Issue: 1 Linguagem: Inglês

10.1093/neuonc/now247

1523-5866

Robert L. Bowman, Qianghu Wang, Ángel Carro, Roel G.W. Verhaak, Massimo Squatrito,

Radiomics and Machine Learning in Medical Imaging

the effects they observed could be influenced by inhibition of other types of Trk receptors or signaling molecules downstream of Trk.We have recently started a series of experiments aiming to verify whether specific TrkB inhibition reduces glioma cell proliferation using ANA-12, a small-molecule selective TrkB antagonist.Our first results showed that ANA-12 effectively and dose-dependently reduces the viability of a human glioblastoma cell line with almost complete disappearance of cultured cells 72 hours after treatment (Fig. 1).Therefore, selective TrkB inhibition might prove to be an effective experimental therapeutic strategy, possibly with fewer off-target toxicities compared with multitarget drugs in patients with astrocytomas harboring oncogenic TrkB.