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P1.06: Lung Nodule Volumetry: Analysis of the Measurement Variation

2016; Elsevier BV; Volume: 11; Issue: 10 Linguagem: Inglês

10.1016/j.jtho.2016.08.028

1556-1380

Diana Penha, Wilson Ezequiel Neto, Klaus Irion, Colin Monaghan, Bruno Hochhegger, Erique Pinto, Edson Marchiori,

Lung Cancer Diagnosis and Treatment

The purpose of the study was to determine the intra-scan variability of volumetric measurements of solid pulmonary nodules. In this retrospective study, 827 consecutive patients that underwent cardiac multi-phase CT scan were evaluated. All the CT exams were performed on a 256-row CT scanner (SIEMENS Somaton Definition Flash) using 0.6mm slice thickness and soft kernel. The image reconstructions were done using 10 phases in 10% of each RR interval. The images were evaluated in the axial plane to identify the lung nodule and after the automatic tool for lung lesions – volumetry was applied. The volume of the nodule was determined two times according with two different phases of the scan for each patient. 66 pulmonary nodules with medium volume of 8mm were included. The mean nodule volumetry difference was 513mm3 or 21.6%. Confidence interval of difference observed on measurements taken on different cardiac phases: Percentile 5= 15mm3 or 0.00%; Percentile 50= 62mm3 or 14%, and Percentile 95= 1696mm2 or 58%. The volume measurements showed significant variability for any one given nodule during a single multi-phase scan (p<0.05). There was no correlation between the volume measurement of the nodule and the difference between the volume measurements. There is significant cardiac phase variability in lung nodule volume measurement.