Cerebral white matter abnormalities in patients with charcot‐marie‐tooth disease
2016; Wiley; Volume: 81; Issue: 1 Linguagem: Inglês
10.1002/ana.24824
ISSN1531-8249
AutoresMina Lee, Chang-Hyun Park, H. K. Chung, Hyeon Jin Kim, Yunseo Choi, Jeong Hyun Yoo, Young Chul Yoon, Young Bin Hong, Ki Wha Chung, Byung‐Ok Choi, Hyang Woon Lee,
Tópico(s)Genetic Neurodegenerative Diseases
ResumoHere, we report the structural evidence of cerebral white matter abnormalities in Charcot‐Marie‐Tooth (CMT) patients and the relationship between these abnormalities and clinical disability. Brain diffusion tensor imaging (DTI) was performed in CMT patients with demyelinating (CMT1A/CMT1E), axonal (CMT2A/CMT2E), or intermediate (CMTX1/DI‐CMT) peripheral neuropathy. Although all patients had normal brain magnetic resonance imaging, all genetic subgroups except CMT1A had abnormal DTI findings indicative of significant cerebral white matter abnormalities: decreased fractional anisotropy and axial diffusivity, and increased radial diffusivity. DTI abnormalities were correlated with clinical disability, suggesting that there is comorbidity of central nervous system damage with peripheral neuropathy in CMT patients. ANN NEUROL 2017;81:147–151
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