Artigo Acesso aberto Revisado por pares

Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol

2010; Wiley; Volume: 8; Issue: 3 Linguagem: Inglês

10.2903/j.efsa.2010.1461

ISSN

1831-4732

Tópico(s)

Muscle metabolism and nutrition

Resumo

EFSA JournalVolume 8, Issue 3 1461 OpinionOpen Access Scientific Opinion on Dietary Reference Values for fats, including saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, trans fatty acids, and cholesterol EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)Search for more papers by this author EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA), EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)Search for more papers by this author First published: 25 March 2010 https://doi.org/10.2903/j.efsa.2010.1461Citations: 309 Panel members: Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser-Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren and Hans Verhagen. Correspondence: [email protected] Acknowledgement: The Panel wishes to thank for the preparation of this Opinion: Carlo Agostoni, Henk van den Berg, Jean-Louis Bresson, Jean-Michel Chardigny, Albert Flynn, Karin Hulshof, Ambroise Martin, Ronald Mensink, Hildegard Przyrembel and EFSA's staff member Silvia Valtueña Martínez. Adoption date: 4 December 2009 Published date: 25 March 2010 Question number: EFSA-Q-2008-466 On request from: European Commission AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract This Opinion of the EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA) deals with the setting of Dietary Reference Values (DRVs) for fats. A lower bound of the reference intake range for total fat of 20 energy % (E%) and an upper bound of 35 E% are proposed. Fat intake in infants can gradually be reduced from 40 E% in the 6 12 month period to 35–40 E% in the 2nd and 3rd year of life. For specific fatty acids the following is proposed: saturated fatty acid (SFA) and trans fatty acid intake should be as low as possible; not to set any DRV for cis-monounsaturated fatty acids; not to formulate a DRV for the intake of total cis-polyunsaturated fatty acids (PUFA); not to set specific values for the n-3/n-6 ratio; to set an Adequate Intake (AI) of 4 E% for linolenic acid; not to set any DRV for arachidonic acid; not to set an UL for total or any of the n 6 PUFA; to set an AI for alpha-linilenic acid (ALA) of 0.5 E% not to set an UL for ALA; to set an AI of 250 mg for eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) for adults; to set an AI of 100 mg DHA for infants (>6 months) and young children <24 months; to increase by 100 200 mg preformed DHA in addition to the AI for adults as an adequate supply of n-3 long chain PUFA during pregnancy and lactation; not to set any DRV for conjugated linoleic acid. For cholesterol it was decided not to propose a reference value beside the limitation on the intake of SFA. References AFSSA (Agence Française de Sécurité Sanitaire des Aliments), 2001. Apports nutritionnels conseillés pour la population française. Editions Tec&Doc, Paris, 605 pp. AFSSA (Agence Française de Sécurité Sanitaire des Aliments), 2005. Risques et bénéfices pour la santé des acides gras trans apportés par les aliments. Recommandations. AFSSA (Agence Française de Sécurité Sanitaire des Aliments), 2009. Avis de l'Agence française de sécurité sanitaire des aliments sur l'estimation des apports en acides gras trans de la population française. Request 2007-SA-220. Aggett PJ, Haschke F, Heine W, Hernell O, Koletzko B, Lafeber H, Ormission A, Rey J and Tormo R, 1994. Committee report: childhood diet and prevention of coronary heart disease. ESPGAN Committee on Nutrition. European Society of Pediatric Gastroenterology and Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 19, 261– 269. Agostoni C, Decsi T, Fewtrell M, Goulet O, Kolacek S, Koletzko B, Michaelsen KF, Moreno L, Puntis J, Rigo J, Shamir R, Szajewska H, Turck D and van Goudoever J, 2008. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 46, 99– 110. Agostoni C, Zuccotti GV, Radaelli G, Besana R, Podesta A, Sterpa A, Rottoli A, Riva E and Giovannini M, 2009. Docosahexaenoic acid supplementation and time at achievement of gross motor milestones in healthy infants: a randomized, prospective, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition, 89, 64– 70. Andersen N, Fagt S, Groth M, Hartkopp H, M⊘ller A, Ovesen L and Warming D, 1996. Danskernes kostvaner (1995). Hovedresultater. Levnedsmiddelstyrelsen, S⊘borg. Angela Liou Y and Innis SM, 2009. Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. Prostaglandins Leukotrienes and Essential Fatty Acids, 80, 201– 206. Anonymous, 2008. National Verzehrs Studie II. Ergebnisbericht, Teil 2. Max Rubner Institut. Bundesforschungsinstitut für Ernährung und Lebensmittel. Karlsruhe. Ascherio A, Hennekens CH, Buring JE, Master C, Stampfer MJ and Willett WC, 1994. Trans-fatty acids intake and risk of myocardial infarction. Circulation, 89, 94– 101. Astorg P, 2004. Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. Cancer Causes and Control, 15, 367– 386. Babin F, Abderrazik M, Favier F, Cristol JP, Leger CL, Papoz L and Descomps B, 1999. Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls: a bioconversion defect can be suspected. European Journal of Clinical Nutrition, 53, 591– 596. Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P and Lau J, 2006. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis, 189, 19– 30. Becker, Haglund M and Wretling S, 2008. Fat and fatty acids in the Swedish diet. Analysis of market baskets 2005. National Food Administration. Report No 17. Becker W and Pearson M, 2002. Riksmaten 1997–1998. Befolkningens kostvanor och näringsintag. Metod- och resultatanalys. Livsmedelsverket, Uppsala. Benito P, Nelson GJ, Kelley DS, Bartolini G, Schmidt PC and Simon V, 2001. The effect of conjugated linoleic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. Lipids, 36, 221– 227. Berry SE, Miller GJ and Sanders TA, 2007a. The solid fat content of stearic acid-rich fats determines their postprandial effects. American Journal of Clinical Nutrition, 85, 1486– 1494. Berry SE, Woodward R, Yeoh C, Miller GJ and Sanders TA, 2007b. Effect of interesterification of palmitic acid-rich triacylglycerol on postprandial lipid and factor VII response. Lipids, 42, 315– 323. Bingham SA, Luben R, Welch A, Wareham N, Khaw KT and Day N, 2003. Are imprecise methods obscuring a relation between fat and breast cancer? Lancet, 362, 212– 214. Birch EE, Garfield S, Castaneda Y, Hughbanks-Wheaton D, Uauy R and Hoffman D, 2007. Visual acuity and cognitive outcomes at 4 years of age in a double-blind, randomized trial of long-chain polyunsaturated fatty acid-supplemented infant formula. Early Human Development, 83, 279– 284. Biró L, Regöly-Mérei A, Nagy K, Pintér B, Beretvás E, Morava E and Antal M, 2007. Dietary habits of schoolchildren: representative survey in metropolitan elementary schools: Part 2. Annals of Nutrition and Metabolism, 51, 454. Bjerve KS, 1989. n-3 fatty acid deficiency in man. Journal of Internal Medicine. Supplement, 731, 171– 175. Bjerve KS, Fischer S, Wammer F and Egeland T, 1989. alpha-Linolenic acid and long-chain omega-3 fatty acid supplementation in three patients with omega-3 fatty acid deficiency: effect on lymphocyte function, plasma and red cell lipids, and prostanoid formation. American Journal of Clinical Nutrition, 49, 290– 300. Bjerve KS, Mostad IL and Thoresen L, 1987. Alpha-linolenic acid deficiency in patients on long-term gastric-tube feeding: estimation of linolenic acid and long-chain unsaturated n-3 fatty acid requirement in man. American Journal of Clinical Nutrition, 45, 66– 77. Boer EJ, Hulshof KFAM and ter Doest D, 2006. Voedselconsumptie bij jonge peuters. Report Nr. 6269. TNO, Zeist. Bonanome A and Grundy SM, 1989. Intestinal absorption of stearic acid after consumption of high fat meals in humans. Journal of Nutrition, 119, 1556– 1560. Borugian MJ, Sheps SB, Kim-Sing C, Van Patten C, Potter JD, Dunn B, Gallagher RP and Hislop TG, 2004. Insulin, macronutrient intake, and physical activity: are potential indicators of insulin resistance associated with mortality from breast cancer? Cancer Epidemiology, Biomarkers and Prevention, 13, 1163– 1172. Boulton TJ and Magarey AM, 1995. Effects of differences in dietary fat on growth, energy and nutrient intake from infancy to eight years of age. Acta Paediatrica, 84, 146– 150. Boyd NF, Stone J, Vogt KN, Connelly BS, Martin LJ and Minkin S, 2003. Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. British Journal of Cancer, 89, 1672– 1685. Brady LM, Lovegrove SS, Lesauvage SV, Gower BA, Minihane AM, Williams CM and Lovegrove JA, 2004. Increased n-6 polyunsaturated fatty acids do not attenuate the effects of long-chain n-3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians. American Journal of Clinical Nutrition, 79, 983– 991. Brenna JT, Salem N, Jr., Sinclair AJ and Cunnane SC, 2009. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukotrienes and Essential Fatty Acids, 80, 85– 91. Brouwer IA, Katan MB and Zock PL, 2004. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. Journal of Nutrition, 134, 919– 922. Brouwer IA, Zock PL, Camm AJ, Bocker D, Hauer RN, Wever EF, Dullemeijer C, Ronden JE, Katan MB, Lubinski A, Buschler H and Schouten EG, 2006. Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. JAMA, 295, 2613– 2619. Browning LM, Krebs JD, Moore CS, Mishra GD, O'Connell MA and Jebb SA, 2007. The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype. Diabetes, Obesity and Metabolism, 9, 70– 80. Bucher HC, Hengstler P, Schindler C and Meier G, 2002. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. American Journal of Medicine, 112, 298– 304. Burdge GC and Wootton SA, 2002. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. British Journal of Nutrition, 88, 411– 420. Butte NF, 1996. Energy requirements of infants. European Journal of Clinical Nutrition, 50 Suppl 1, S24– 36. Butte NF and King JC, 2005. Energy requirements during pregnancy and lactation. Public Health Nutrition, 8, 1010– 1027. Calder PC, 2006. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. American Journal of Clinical Nutrition, 83, 1505S– 1519S. Carnielli VP, Luijendijk IH, Van Goudoever JB, Sulkers EJ, Boerlage AA, Degenhart HJ and Sauer PJ, 1996. Structural position and amount of palmitic acid in infant formulas: effects on fat, fatty acid, and mineral balance. Journal of Pediatric Gastroenterology and Nutrition, 23, 553– 560. Carver JD, Benford VJ, Han B and Cantor AB, 2001. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Research Bulletin, 56, 79– 85. Caspi A, Williams B, Kim-Cohen J, Craig IW, Milne BJ, Poulton R, Schalkwyk LC, Taylor A, Werts H and Moffitt TE, 2007. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proceedings of the National Academy of Sciences of the United States of America, 104, 18860– 18865. Castetbon K, Vernay M, Malon A, Salanave B, Deschamps V, Roudier C, Oleko A, Szego E and Hercberg S, 2009. Dietary intake, physical activity and nutritional status in adults: the French nutrition and health survey (ENNS, 2006–2007). British Journal of Nutrition, 102, 733– 743. Cederholm T and Palmblad J, 2010. Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? Current Opinions in Clinical Nutrition Metabolic Care, 13, 150– 5. Chajes V, Thiebaut AC, Rotival M, Gauthier E, Maillard V, Boutron-Ruault MC, Joulin V, Lenoir GM and Clavel-Chapelon F, 2008. Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study. American Journal of Epidemiology, 167, 1312– 1320. Chardigny JM, Destaillats F, Malpuech-Brugère C, Moulin J, Bauman DE, Lock AL, Barbano DM, Mensink RP, Bezelgues JB, Chaumont P, Combe N, Cristiani I, Joffre F, German B, Dionisi F, Boirie Y and Sébédio JL, 2008. Do trans fatty acids from industrially produced sources and from natural sources have the same effect on cardiovascular diseases risk factors in healthy subjects? Results of the trans Fatty Acids Collaboation (TRANSFACT) study. American Journal of Clinical Nutrition, 87, 558– 566. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, Goodman MT, Giuliano AE, Karanja N, McAndrew P, Hudis C, Butler J, Merkel D, Kristal A, Caan B, Michaelson R, Vinciguerra V, Del Prete S, Winkler M, Hall R, Simon M, Winters BL and Elashoff RM, 2006. Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. Journal of the National Cancer Institute, 98, 1767– 1776. Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA and Willett WC, 2003. Premenopausal fat intake and risk of breast cancer. Journal of the National Cancer Institute, 95, 1079– 1085. Cifkova R and Skodova Z, 2004. [Longitudinal trends in major cardiovascular disease risk factors in the Czech population]. Casopis Lekaru Ceskych, 143, 219– 226. Clandinin MT, 1999. Brain development and assessing the supply of polyunsaturated fatty acid. Lipids, 34, 131– 137. Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR and Chance GW, 1980a. Intrauterine fatty acid accretion rates in human brain: implications for fatty acid requirements. Early Human Development, 4, 121– 129. Clandinin MT, Chappell JE, Leong S, Heim T, Swyer PR and Chance GW, 1980b. Extrauterine fatty acid accretion in infant brain: implications for fatty acid requirements. Early Human Development, 4, 131– 138. Clarke R, Frost C, Collins R, Appleby P and Peto R, 1997. Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies. BMJ (Clinical Research Ed.), 314, 112– 117. Cole GM, Ma QL and Frautschy SA, 2009. Omega-3 fatty acids and dementia. Prostaglandins Leukotriens and Essential Fatty Acids, 81, 213– 21. Couet C, Delarue J, Ritz P, Antoine JM and Lamisse F, 1997. Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. International Journal of Obesity and Related Metabolic Disorders, 21, 637– 643. Crowe FL, Key TJ, Appleby PN, Travis RC, Overvad K, Jakobsen MU, Johnsen NF, Tjonneland A, Linseisen J, Rohrmann S, Boeing H, Pischon T, Trichopoulou A, Lagiou P, Trichopoulos D, Sacerdote C, Palli D, Tumino R, Krogh V, Bueno-de-Mesquita HB, Kiemeney LA, Chirlaque MD, Ardanaz E, Sanchez MJ, Larranaga N, Gonzalez CA, Quiros JR, Manjer J, Wirfalt E, Stattin P, Hallmans G, Khaw KT, Bingham S, Ferrari P, Slimani N, Jenab M and Riboli E, 2008. Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition, 87, 1405– 1413. Cunnane SC, Francescutti V, Brenna JT and Crawford MA, 2000. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids, 35, 105– 111. D'Amicis A, 2000. Il quadro nutrizionale della popolazione in Italia. La Rivista di Scienza dell'Alimentazione, 3, 7– 11. D-A-CH (Deutsche Gesellschaft für Ernährung - Österreichische Gesellschaft für Ernährung - Schweizerische Gesellschaft für Ernährungsforschung - Schweizerische Vereinigung für Ernährung), 2000. Referenzwerte für die Nährstoffzufuhr. Umschau Braus Verlag, Frankfurt am Main. D-A-CH (Deutsche Gesellschaft für Ernährung - Österreichische Gesellschaft für Ernährung - Schweizerische Gesellschaft für Ernährungsforschung - Schweizerische Vereinigung für Ernährung), 2008. Referenzwerte für die Nährstoffzufuhr. Umschau Braus Verlag, Frankfurt am Main. De Vriese S, Huybrechts I, Moreau M and Van Oyen H, 2006. De Belgische Voedselconsumptiepeiling 1 - 2004. Brussel: Wetenschappelijk Instituut Volksgezondheid. [WIV/EPI Reports Nr. 2006–016]. Deharveng G, Charrondiere UR, Slimani N, Southgate DA and Riboli E, 1999. Comparison of nutrients in the food composition tables available in the nine European countries participating in EPIC. European Prospective Investigation into Cancer and Nutrition. European Journal of Clinical Nutrition, 53, 60– 79. Demmelmair H, Feldl F, Horvath I, Niederland T, Ruszinko V, Raederstorff D, De Min C, Muggli R and Koletzko B, 2001. Influence of formulas with borage oil or borage oil plus fish oil on the arachidonic acid status in premature infants. Lipids, 36, 555– 566. DGE (Deutsche Gesellschaft für Ernährung), 2006. Evidenzbasierte Leitlinie Fettkonsum und Prävention ausgewählter ernährungsmitbedingter Krankheiten. Deutsche Gesellschaft für Ernährung, Bonn. Djousse L and Gaziano JM, 2008. Egg consumption and risk of heart failure in the Physicians' Health Study. Circulation, 117, 512– 516. DoH (Department of Health), 1991. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report of the Panel on Dietary Reference Values of the Committee on Medical Aspects of Food Policy. HMSO, London. Dunstan JA, Simmer K, Dixon G and Prescott SL, 2008. Cognitive assessment of children at age 2.5 years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. Arch. Dis. Child Fetal Neonatal 93, 45– 50. EFSA (European Food Safety Authority), 2004. Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies on a request from the Commission related to the presence of trans fatty acids in foods and the effect on human health of the consumption of trans fatty acids. The EFSA Journal, 81, 1– 49. EFSA (European Food Safety Authority), 2009. Scientific Opinion of the Panel on Dietetic Products, Nutrition and Allergies on a request from Mead Johnson Nutritionals on DHA and ARA and visual development. The EFSA Journal, 94, 1– 14. el Boustani S, Causse JE, Descomps B, Monnier L, Mendy F and Crastes de Paulet A, 1989. Direct in vivo characterization of delta 5 desaturase activity in humans by deuterium labeling: effect of insulin. Metabolism: Clinical and Experimental, 38, 315– 321. I Elmadfa, ed 2009. European Nutrition and Health Report 2009. Forum of Nutrition Vol. 62. 'Karger, Basel, 426 pp. Elmadfa I, Freisling H, Nowak V, Hofstädter D, Hasenegger V, Ferge M, Fröhler M, Fritz K, Meyer AL, Putz P, Rust P, Grossgut R, Mischek D, Kiefer I, Schätzer M, Spanblöchel J, Sturtzel B, Wagner K-H, Zilberszac A, Vojir F and Plsek K, 2009. Österreichischer Ernährungsbericht 2008. Emken EA, Adlof RO and Gulley RM, 1994. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. Biochimica et Biophysica Acta, 1213, 277– 288. Enghardt-Barbieri H, Pearson M and Becker W, 2006. Riksmaten – Barn 2003. Livsmedels – och näringsintag bland barn i Svenge. Livsmedelsverket, Uppsala. Eurodiet, 2000. Eurodiet core report: Nutrition and diet for healthy lifestyles in Europe. Science and policy implications. Available from: ec.europa.eu/health/ph_determinants/life_style/nutrition/report01_en.pdf FAO/WHO (Food and Agriculture Organization/World Health Organization), 1994. Fats and oils in human nutrition. Report of a joint expert consultation, Rome, 19–26 October 1993. FAO Food and Nutrition Papers 57. Farquharson J, Cockburn F, Patrick WA, Jamieson EC and Logan RW, 1992. Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet, 340, 810– 813. Finch S, Doyle W, Lowe C, Bates CJ, Prentice A, Smitrhers G and Clarke PC, 1998. National Diet and Nutriton Survey: people aged 65 years and over. TSO, London. Fjeld CR, Schoeller DA and Brown KH, 1989. A new model for predicting energy requirements of children during catch-up growth developed using doubly labeled water. Pediatric Research, 25, 503– 508. Fotuhi M, Mohassel P and Yaffe K, 2009. Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Nature Clinical Practice in Neurology, 5, 140– 52. Friedman G and Goldberg SJ, 1976. An evaluation of the safety of a low-saturated-fat, low-cholesterol diet beginning in infancy. Pediatrics, 58, 655– 657. Fritsche K, 2006. Fatty acids as modulators of the immune response. Annual Review of Nutrition, 26, 45– 73. Galeone C, Talamini R, Levi F, Pelucchi C, Negri E, Giacosa A, Montella M, Franceschi S and La Vecchia C, 2007. Fried foods, olive oil and colorectal cancer. Annals of Oncology, 18, 36– 39. Gardner CD and Kraemer HC, 1995. Monounsaturated versus polyunsaturated dietary fat and serum lipids. A meta-analysis. Arteriosclerosis, Thrombosis, and Vascular Biology, 15, 1917– 1917. Gaullier JM, Halse J, Hoivik HO, Hoye K, Syvertsen C, Nurminiemi M, Hassfeld C, Einerhand A, O'Shea M and Gudmundsen O, 2007. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. British Journal of Nutrition, 97, 550– 560. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H and Gudmundsen O, 2004. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition, 79, 1118– 1125. Gebauer SK, Psota TL and Kris-Etherton PM, 2007. The diversity of health effects of individual trans fatty acid isomers. Lipids, 42, 787– 799. Geelen A, Schouten JM, Kamphuis C, Stam BE, Burema J, Renkema JM, Bakker EJ, Van't Veer P and Kampman E, 2007. Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies. American Journal of Epidemiology, 166, 1116– 1125. Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR and Kok FJ, 2002. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. Journal of Hypertension, 20, 1493– 1499. Gibson RA, Neumann MA and Makrides M, 1997. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. European Journal of Clinical Nutrition, 51, 578– 584. Gibson RS, MacDonald CA, Smit Vanderkooy PD, McLennan CE and Mercer NJ, 1993. Dietary fat patterns of some Canadian preschool children in relation to indices of growth, iron, zinc, and dietary status. Journal of the Canadian Dietetic Association, 54, 33– 37. Giugliano D, Ceriello A and Esposito K, 2006. The effects of diet on inflammation: emphasis on the metabolic syndrome. Journal of the American College of Cardiology, 48, 677– 685. Gonzalez CA, 2006. The European Prospective Investigation into Cancer and Nutrition (EPIC). Public Health Nutrition, 9, 124– 126. Goyens PL and Mensink RP, 2006. Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. European Journal of Clinical Nutrition, 60, 978– 984. Goyens PL, Spilker ME, Zock PL, Katan MB and Mensink RP, 2006. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. American Journal of Clinical Nutrition, 84, 44– 53. GR (Gezondheidsraad), 2001. Dietary Reference Intakes: energy, proteins, fats and digestible carbohydrates. Publication no. 2001/19R. Healtho Council of the Netherlands, The Hague. GR (Gezondheidsraad), 2006. Guidelines for healthy nutrition 2006. Publication no. 2006/21E. Healtho Council of the Netherlands, The Hague, 110 pp. Gregory J, Lowe S, Bates CJ, Prentice A, Jackson LV, Smithers G, Wenlock R and Farron M, 2000. National Diet and Nutrition Survey: young people aged 4 to 18 years. TSO, London. Griffin MD, Sanders TA, Davies IG, Morgan LM, Millward DJ, Lewis F, Slaughter S, Cooper JA, Miller GJ and Griffin BA, 2006. Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45–70 y: the OPTILIP Study. American Journal of Clinical Nutrition, 84, 1290– 1298. Hall MN, Chavarro JE, Lee IM, Willett WC and Ma J, 2008. A 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men. Cancer Epidemiology, Biomarkers and Prevention, 17, 1136– 1143. Hansen AE, Wiese HF, Boelsche AN, Haggard ME, Adam DJD and Davis H, 1963. Role of linoleic acid in infant nutrition: clinical and chemical study of 428 infants fed on milk mixtures varying in kind and amount of fat. Pediatrics, 31, 171– 192. Harris WS, Kris-Etherton PM and Harris KA, 2008. Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults. Current Atherosclerosis Reports, 10, 503– 509. He K, Merchant A, Rimm EB, Rosner BA, Stampfer MJ, Willett WC and Ascherio A, 2003. Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study. BMJ (Clinical Research Ed.), 327, 777– 782. He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, Goldbourt U and Greenland P, 2004b. Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke, 35, 1538– 1542. He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR and Greenland P, 2004a. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation, 109, 2705– 2711. Helland IB, Smith L, Saarem K, Saugstad OD and Drevon CA, 2003. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics, 111, e39– 44. Henderson L, Gregory J, Irving K and Swan G, 2003. The National Diet & Nutrition Survey: adults aged 19 to 64 years. Volume 2. Energy, protein, carbohydrate, fat and alcohol intake. TSO, London. Henon G, Kemeny Z, Recseg K, Zwobada F and Kovari K, 1999. Deodorization of vegetable oils. Part I: Modelling the geometrical isomerization of polyunsaturated fatty acids. Journal of the American Oil Chemists Society, 76, 73– 81. HHS/USDA (US Department of Health and Human Services/US Department of Agriculture), 2005. Dietary Guidelines for Americans. Hibbeln JR, 2002. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. Journal of Affective Disorders, 69, 15– 29. Hilbig A and Kersting M, 2006. Effect of Age and time on energy and mac

Referência(s)