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A 12‐hour Evaluation of the Analgesic Efficacy of Diflunisal, Propoxyphene, A Propoxyphene‐Acetaminophen Combination, and Placebo in Postoperative Oral Surgery Pain

1982; Wiley; Volume: 2; Issue: 1 Linguagem: Inglês

10.1002/j.1875-9114.1982.tb03171.x

1875-9114

James A. Forbes, Virginia M. Foor, Michael W. Bowser, Joseph P. Calderazzo, Robert W. Shackleford, William T. Beaver,

Pain Management and Opioid Use

One‐hundred thirty‐two outpatients with pain following oral surgery were randomly assigned, on a double‐blind basis, to a single oral dose of diflunisal 500 or 1000 mg, propoxyphene napsylate 100 mg, a combination of propoxyphene napsylate 100 mg with acetaminophen 650 mg, or placebo. Using a self‐rating record, subjects rated their pain and its relief hourly for 12 hours after medication. Measures of total and peak analgesia were derived from the patient's subjective reports. Diflunisal 500 and 1000 mg were significantly superior to placebo and propoxyphene alone for every measure of total and peak analgesia, and the effect of diflunisal persisted for 12 hours. Diflunisal 1000 mg was significantly superior to the propoxyphene‐acetaminophen combination for all measures of analgesia. Although the propoxyphene‐acetaminophen combination was significantly superior to placebo for most measures of analgesia, propoxyphene alone was significantly superior for only two measures. Adverse effects attributed to all drugs were mild and transitory.