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Racemic alkaloids from the fungus Ganoderma cochlear

2016; Elsevier BV; Volume: 116; Linguagem: Inglês

10.1016/j.fitote.2016.11.011

1873-6971

Xinlong Wang, Man Dou, Qi Luo, Cheng Li-zhi, Yong‐Ming Yan, Rong‐Tao Li, Yong‐Xian Cheng,

Slime Mold and Myxomycetes Research

Seven pairs of new alkaloid enantiomers, ganocochlearines C − I (1, 3–8), and three pairs of known alkaloids were isolated from the fruiting bodies of Ganoderma cochlear. The chemical structures of new compounds were elucidated on the basis of 1D and 2D NMR data. The absolute configurations of compounds 1, 3–10 were assigned by ECD calculations. Biological activities of these isolates against renal fibrosis were accessed in rat normal or diseased renal interstitial fibroblast cells. Importantly, the plausible biosynthetic pathway for this class of alkaloids was originally proposed.