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BIBTEX RIS

Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation

2016; Rockefeller University Press; Volume: 215; Issue: 3 Linguagem: Inglês

10.1083/jcb.201606042

ISSN

1540-8140

Autores

Bryne Ulmschneider, Bree K. Grillo‐Hill, Marimar Benitez, Dinara R. Azimova, Diane L. Barber, Todd G. Nystul,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

Despite extensive knowledge about the transcriptional regulation of stem cell differentiation, less is known about the role of dynamic cytosolic cues. We report that an increase in intracellular pH (pHi) is necessary for the efficient differentiation of Drosophila adult follicle stem cells (FSCs) and mouse embryonic stem cells (mESCs). We show that pHi increases with differentiation from FSCs to prefollicle cells (pFCs) and follicle cells. Loss of the Drosophila Na

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