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Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types

2016; Hindawi Publishing Corporation; Volume: 2016; Linguagem: Inglês

10.1155/2016/8346198

2314-4378

André Fonseca, Vandeclécio L. da Silva, Marbella Maria da Fonsêca, Isabella Tanus Job e Meira, Thayná E. da Silva, José Eduardo Kroll, André M. Ribeiro-dos-Santos, Cléber R. Freitas, Raimundo Furtado, Jorge Estefano de Souza, Beatriz Stransky, Sandro J. de Souza,

Cancer-related gene regulation

It is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. Therefore, a precise characterization of the surfaceome set in different types of tumor is needed. Using TCGA data from 15 different tumor types and a new method to identify cancer genes, the S -score, we identified several potential therapeutic targets within the surfaceome set. This allowed us to expand a previous analysis from us and provided a clear characterization of the human surfaceome in the tumor landscape. Moreover, we present evidence that a three-gene set—WNT5A, CNGA2, and IGSF9B—can be used as a signature associated with shorter survival in breast cancer patients. The data made available here will help the community to develop more efficient diagnostic and therapeutic tools for a variety of tumor types.