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BIBTEX RIS

Life course socioeconomic adversities and 10-year risk of cardiovascular disease: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health

2016; Springer Science+Business Media; Volume: 62; Issue: 2 Linguagem: Inglês

10.1007/s00038-016-0928-3

1661-8564

Dayse Rodrigues de Sousa Andrade, Lidyane do Valle Camelo, Rodrigo Citton Padilha dos Reis, Itamar S Santos, Antônio Luiz Pinho Ribeiro, Luana Giatti, Sandhi Maria Barreto,

Global Health Care Issues

To investigate whether life course exposure to adverse socioeconomic positions (SEP) as well as maintaining a low SEP or decreasing the SEP intra- and intergeneration was associated with an increased 10-year cardiovascular disease (CVD) risk predicted by the Framingham Risk Score. This is a cross-sectional analysis of baseline data (2008–2010) of 13,544 active workers from ELSA-Brasil cohort. Maternal education, leg length, social class of first occupation and education were used to evaluate childhood, youth and adulthood SEP. After considering adulthood SEP, exposure to early-life low SEP remained associated with an increased 10-year CVD risk. The 10-year CVD risk also rose as the number of exposures to low SEP throughout life increased. Compared to individuals in high-stable intragenerational trajectory, those in upward, downward, or stable low trajectory presented higher 10-year CVD risk. Increasing individuals' SEP over generation showed no increased risk of 10-year CVD risk compared to individuals in high-stable trajectory. Childhood may be a critical period for exposures to social adversities. Life course low SEP may also affect the 10-year CVD risk via accumulation of risk and social mobility.