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Open Targets: a platform for therapeutic target identification and validation

2016; Oxford University Press; Volume: 45; Issue: D1 Linguagem: Inglês

10.1093/nar/gkw1055

1362-4962

Gautier Koscielny, Peter An, Denise Carvalho‐Silva, Jennifer A. Cham, Luca Fumis, Rippa Gasparyan, Samiul Hasan, Nikiforos Karamanis, Michael E. Maguire, Eliseo Papa, Andrea Pierleoni, Miguel Pignatelli, Theo Platt, Francis Rowland, Priyanka Wankar, A. Patrícia Bento, Tony Burdett, Antonio Fabregat, Simon Forbes, Anna Gaulton, Cristina González, Henning Hermjakob, Anne Hersey, S Jupe, Şenay Kafkas, Maria Keays, Catherine Leroy, Francisco-Javier Lopez, María Paula Magariños, James Malone, Johanna McEntyre, Alfonso Muñoz-Pomer Fuentes, Claire O’Donovan, Irene Papatheodorou, Helen Parkinson, Barbara P. Palka, Justin Paschall, Robert Petryszak, Ploy N. Pratanwanich, Sirarat Sarntivijal, Gary Saunders, Konstantinos Sidiropoulos, Thomas B. Smith, Zbysław Sońdka, Oliver Stegle, Amy Tang, E. B. Turner, Brendan Vaughan, Olga Vrousgou, Xavier Watkins, María Martín, Philippe Sanséau, Jessica Vamathevan, Ewan Birney, Jeffrey C. Barrett, Ian Dunham,

vaccines and immunoinformatics approaches

We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. The platform is designed to support identification and prioritization of biological targets for follow-up. Each drug target is linked to a disease using integrated genome-wide data from a broad range of data sources. The platform provides either a target-centric workflow to identify diseases that may be associated with a specific target, or a disease-centric workflow to identify targets that may be associated with a specific disease. Users can easily transition between these target- and disease-centric workflows. The Open Targets Validation Platform is accessible at https://www.targetvalidation.org.