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Diterpenes as lead molecules against neglected tropical diseases
2016; Wiley; Volume: 31; Issue: 2 Linguagem: Inglês
10.1002/ptr.5749
ISSN1099-1573
AutoresMarcus Vinícius Oliveira Barros de Alencar, João Marcelo de Castro e Sousa, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Gilberto Santos Cerqueira, Fernanda Regina de Castro Almeida, Antônia Maria das Graças Lopes Citó, Paulo Michel Pinheiro Ferreira, José Arimatéia Dantas Lopes, Ana Amélia de Carvalho Melo Cavalcante, Muhammad Torequl Islam,
Tópico(s)Traditional and Medicinal Uses of Annonaceae
ResumoPhytotherapy ResearchVolume 31, Issue 2 p. 175-201 Review Diterpenes as lead molecules against neglected tropical diseases Marcus Vinícius Oliveira Barros de Alencar, Marcus Vinícius Oliveira Barros de Alencar Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorJoão Marcelo de Castro e Sousa, João Marcelo de Castro e Sousa Department of Biological Sciences, Federal University of Piauí, Picos, (Piauí), 64.607-670 Brazil Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorHercília Maria Lins Rolim, Hercília Maria Lins Rolim Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorMaria das Graças Freire de Medeiros, Maria das Graças Freire de Medeiros Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorGilberto Santos Cerqueira, Gilberto Santos Cerqueira Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Postgraduate Program in Biotechnology, Biotechnology and Biodiversity Center for Research (BIOTEC), Federal University of Piauí (LAFFEX), Parnaíba, Piauí, 64.218-470 BrazilSearch for more papers by this authorFernanda Regina de Castro Almeida, Fernanda Regina de Castro Almeida Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorAntônia Maria das Graças Lopes Citó, Antônia Maria das Graças Lopes Citó Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Chemistry, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorPaulo Michel Pinheiro Ferreira, Paulo Michel Pinheiro Ferreira Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorJosé Arimatéia Dantas Lopes, José Arimatéia Dantas Lopes Department of Chemistry, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorAna Amélia de Carvalho Melo-Cavalcante, Ana Amélia de Carvalho Melo-Cavalcante Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorMd. Torequl Islam, Corresponding Author Md. Torequl Islam rbiotufpi.br@gmail.com Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Pharmacy, Southern University Bangladesh, Mehedibag, Chittagong, 4000 Bangladesh Correspondence to: Md. Torequl Islam, Department of Pharmacy, Southern University Bangladesh, Mehedibag (Chittagong)-4000, Bangladesh. E-mail: rbiotufpi.br@gmail.comSearch for more papers by this author Marcus Vinícius Oliveira Barros de Alencar, Marcus Vinícius Oliveira Barros de Alencar Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorJoão Marcelo de Castro e Sousa, João Marcelo de Castro e Sousa Department of Biological Sciences, Federal University of Piauí, Picos, (Piauí), 64.607-670 Brazil Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorHercília Maria Lins Rolim, Hercília Maria Lins Rolim Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorMaria das Graças Freire de Medeiros, Maria das Graças Freire de Medeiros Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorGilberto Santos Cerqueira, Gilberto Santos Cerqueira Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Postgraduate Program in Biotechnology, Biotechnology and Biodiversity Center for Research (BIOTEC), Federal University of Piauí (LAFFEX), Parnaíba, Piauí, 64.218-470 BrazilSearch for more papers by this authorFernanda Regina de Castro Almeida, Fernanda Regina de Castro Almeida Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorAntônia Maria das Graças Lopes Citó, Antônia Maria das Graças Lopes Citó Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Chemistry, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorPaulo Michel Pinheiro Ferreira, Paulo Michel Pinheiro Ferreira Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorJosé Arimatéia Dantas Lopes, José Arimatéia Dantas Lopes Department of Chemistry, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorAna Amélia de Carvalho Melo-Cavalcante, Ana Amélia de Carvalho Melo-Cavalcante Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550 BrazilSearch for more papers by this authorMd. Torequl Islam, Corresponding Author Md. Torequl Islam rbiotufpi.br@gmail.com Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, 64.049-550 Brazil Department of Pharmacy, Southern University Bangladesh, Mehedibag, Chittagong, 4000 Bangladesh Correspondence to: Md. Torequl Islam, Department of Pharmacy, Southern University Bangladesh, Mehedibag (Chittagong)-4000, Bangladesh. E-mail: rbiotufpi.br@gmail.comSearch for more papers by this author First published: 29 November 2016 https://doi.org/10.1002/ptr.5749Citations: 23Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Nowadays, neglected tropical diseases (NTDs) are reported to be present everywhere. Poor and developing areas in the world have received great attention to NTDs. Drug resistance, safety profile, and various challenges stimulate the search for alternative medications. Plant-based drugs are viewed with great interest, as they are believed to be devoid of side effects. Diterpenes, a family of essential oils, have showed attractive biological effects. A systematic review of the literature was carried out to summarize available evidences of diterpenes against NTDs. For this, databases were searched using specific search terms. Among the 2338 collected reports, a total of 181 articles were included in this review. Of them, 148 dealt with investigations using single organisms, and 33 used multiple organisms. No mechanisms of action were reported in the case of 164 reports. A total of 93.92% were related to nonclinical studies, and 4.42% and 1.66% dealt with preclinical and clinical studies, respectively. The review displays that many diterpenes are effective upon Chagas disease, chikungunya, echinococcosis, dengue, leishmaniasis, leprosy, lymphatic filariasis, malaria, schistosomiasis, and tuberculosis. Indeed, diterpenes are amazing drug candidates against NTDs. Copyright © 2016 John Wiley & Sons, Ltd. Citing Literature Volume31, Issue2February 2017Pages 175-201 RelatedInformation
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