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Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

2017; Nature Portfolio; Volume: 49; Issue: 3 Linguagem: Inglês

10.1038/ng.3752

1546-1718

Brian D. Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V. Wain, Ian P. Hall, Victoria E. Jackson, Annah B. Wyss, Stephanie J. London, Kari E. North, Nora Franceschini, David P. Strachan, Terri H. Beaty, John E. Hokanson, James D. Crapo, Peter J. Castaldi, Robert Chase, Traci M. Bartz, Susan R. Heckbert, Bruce M. Psaty, Sina A. Gharib, Pieter Zanen, Jan Willem J. Lammers, Matthijs Oudkerk, Harry J.M. Groen, Nicholas Locantore, Ruth Tal‐Singer, Stephen I. Rennard, Jørgen Vestbo, Wim Timens, Peter D. Paré, Jeanne C. Latourelle, Josée Dupuis, George O'connor, Jemma B. Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon‐Mok Oh, Judith M. Vonk, Harry J. de Koning, Shuguang Leng, Steven A. Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin‐Qun Wang, Stephen S. Rich, R. Graham Barr, David Sparrow, Augusto A. Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy Brusselle, Bruno H. Stricker, André G. Uitterlinden, Elizabeth J. Ampleford, Eugene R. Bleecker, Prescott G. Woodruff, Deborah A. Meyers, Dandi Qiao, David A. Lomas, Jae‐Joon Yim, Deog Kyeom Kim, I Hawryłkiewicz, Paweł Śliwiński, Megan Hardin, Tasha E. Fingerlin, David A. Schwartz, Dirkje S. Postma, William MacNee, Martin D. Tobin, Edwin K. Silverman, H. Marike Boezen, Michael H. Cho,

Pediatric health and respiratory diseases

Michael Cho and colleagues report a genome-wide association study of risk for chronic obstructive pulmonary disease (COPD) in a large, multi-ancestry cohort. They identify 22 genome-wide significant loci, including 13 not previously associated with COPD and 4 not previously associated with any lung function trait. Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide1. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10−6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples2,3,4,5,6,7, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis8,9 (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity10. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.