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A scored human protein–protein interaction network to catalyze genomic interpretation

2016; Nature Portfolio; Volume: 14; Issue: 1 Linguagem: Inglês

10.1038/nmeth.4083

1548-7105

Taibo Li, Rasmus Wernersson, Rasmus Borup Hansen, Heiko Horn, Johnathan Mercer, Greg Slodkowicz, Christopher T. Workman, Olga Rigina, Kristoffer Rapacki, Hans H Stærfeldt, Søren Brunak, Thomas Jensen, Kasper Lage,

Microbial Metabolic Engineering and Bioproduction

InWeb_InBioMap (InWeb_IM for short) is a scored, integrated human protein–protein interaction network resource aggregated from public, experimentally determined protein–protein interactions. The resource enables functional interpretation of large-scale genomics data. Genome-scale human protein–protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein–protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.