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Salivary biomarkers as tools for oral squamous cell carcinoma diagnosis: A systematic review

2016; Wiley; Volume: 39; Issue: 4 Linguagem: Inglês

10.1002/hed.24650

1097-0347

Vitor de Toledo Stuani, Cássia Maria Fischer Rubira, Adriana Campos Passanezi Sant’Ana, Paulo Sérgio da Silva Santos,

Salivary Gland Disorders and Functions

Background The oral squamous cell carcinoma (OSCC) survival rate is influenced by the fact that diagnoses occur mostly in late stages of the disease. Thus, there is a clear contribution in the early findings, making the use of minimally invasive techniques for diagnosis, such as analysis of salivary markers, interesting tools. Methods A systematic review was performed with all studies that establish a comparison between the levels of saliva-based markers found in patients with OSCC compared with cancer-free individuals. Results Twenty-eight studies were included. Of them, only 12 showed some caution with oral conditions before sample collection. A wide range of potential markers was evaluated; however, the comparison between studies was impaired because each marker was hardly explored by more than 1 article. Conclusion The lack of methodological criteria within studies and the absence of consensus on marker choice are obstacles for future researches. © 2016 Wiley Periodicals, Inc. Head Neck 39: 797–811, 2017