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What does PD-L1 positive or negative mean?

2016; Rockefeller University Press; Volume: 213; Issue: 13 Linguagem: Inglês

10.1084/jem.20161462

1540-9538

Antoni Ribas, Siwen Hu‐Lieskovan,

Immunotherapy and Immune Responses

Expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) is used to select patients and analyze responses to anti–PD-1/L1 antibodies. The expression of PD-L1 is regulated in different ways, which leads to a different significance of its presence or absence. PD-L1 positivity may be a result of genetic events leading to constitutive PD-L1 expression on cancer cells or inducible PD-L1 expression on cancer cells and noncancer cells in response to a T cell infiltrate. A tumor may be PD-L1 negative because it has no T cell infiltrate, which may be reversed with an immune response. Finally, a tumor that is unable to express PD-L1 because of a genetic event will always be negative for PD-L1 on cancer cells.