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Long‐Term Real‐Time In Vivo Drug Release Monitoring with AIE Thermogelling Polymer

2016; Wiley; Volume: 13; Issue: 7 Linguagem: Inglês

10.1002/smll.201603404

1613-6829

Sing Shy Liow, Qingqing Dou, Dan Kai, Zibiao Li, Sigit Sugiarto, Chris Y. Y. Yu, Ryan T. K. Kwok, Xiaohong Chen, Yun‐Long Wu, Seow Theng Ong, Atish Kizhakeyil, Navin Kumar Verma, Ben Zhong Tang, Xian Jun Loh,

Hydrogels: synthesis, properties, applications

A new drug concentration meter is developed. In vivo drug release can be monitored precisely via a self-indicating drug delivery system consisting of a new aggregation-induced emission thermoresponsive hydrogel. By taking the advantage of a self-indicating system, one can easily detect the depletion of drugs, and reinject to maintain a dosage in the optimal therapeutic window. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.