Produção Nacional
Revisado por pares
Western diet in the perinatal period promotes dysautonomia in the offspring of adult rats
2016; Cambridge University Press; Volume: 8; Issue: 2 Linguagem: Inglês
10.1017/s2040174416000623
ISSN2040-1752
AutoresRobervan Vidal‐Santos, Fabrício Nunes Macedo, Michael Nadson Santos Santana, Vitor Ulisses de Melo, José Luiz de Brito Alves, Márcio Roberto Viana dos Santos, Larissa Brito, Elizabeth do Nascimento, João Henrique Costa‐Silva, Valter Joviniano Santana‐Filho,
Tópico(s)Diet and metabolism studies
ResumoThe present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother’s diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram. Cardiovascular parameters were measured on the same period. Autonomic nervous system modulation was evaluated by spectrum analysis of heart rate (HR) and systolic arterial pressure (SAP). The W increased glycemia (123±2 v . 155±2 mg/dl), low-density lipoprotein (15±1 v . 31±2 mg/dl), triglycerides (49±1 v . 85±2 mg/dl), total cholesterol (75±2 v . 86±2 mg/dl), and decreased high-density lipoprotein (50±4 v . 38±3 mg/dl), as well as increased body mass (209±4 v . 229±6 g) than C. Furthermore, the W showed higher SAP (130±4 v . 157±2 mmHg), HR (357±10 v . 428±14 bpm), sympathetic modulation to vessels (2.3±0.56 v . 6±0.84 mmHg 2 ) and LF/HF ratio (0.15±0.01 v . 0.7±0.2) than C. These findings suggest that a western diet during pregnancy and lactation leads to overweight associated with autonomic misbalance and hypertension in adulthood.
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