Echocardiographic predictors of outcome in patients with chronic obstructive pulmonary disease
2016; Wiley; Volume: 45; Issue: 4 Linguagem: Inglês
10.1002/jcu.22433
ISSN1097-0096
AutoresIvan Stanković, Robert Marčun, Aleksandra Janićijević, Jerneja Farkaš, Saša Kadivec, Ivan Ilić, Aleksandar Nešković, Mitja Lainščak,
Tópico(s)Cardiovascular Function and Risk Factors
ResumoJournal of Clinical UltrasoundVolume 45, Issue 4 p. 211-221 Research Article Echocardiographic predictors of outcome in patients with chronic obstructive pulmonary disease Ivan Stankovic MD, Ivan Stankovic MD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorRobert Marcun MD, PhD, Robert Marcun MD, PhD University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, SloveniaSearch for more papers by this authorAleksandra Janicijevic MD, Aleksandra Janicijevic MD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorJerneja Farkas MD, PhD, Jerneja Farkas MD, PhD Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaSearch for more papers by this authorSasa Kadivec PhD, Sasa Kadivec PhD University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, SloveniaSearch for more papers by this authorIvan Ilic MD, Ivan Ilic MD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorAleksandar N. Neskovic MD, PhD, Aleksandar N. Neskovic MD, PhD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorMitja Lainscak MD, PhD, Corresponding Author Mitja Lainscak MD, PhD mitja.lainscak@guest.arnes.si Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Department of Cardiology, General Hospital Celje, Celje, SloveniaCorrespondence to: M. LainscakSearch for more papers by this author Ivan Stankovic MD, Ivan Stankovic MD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorRobert Marcun MD, PhD, Robert Marcun MD, PhD University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, SloveniaSearch for more papers by this authorAleksandra Janicijevic MD, Aleksandra Janicijevic MD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorJerneja Farkas MD, PhD, Jerneja Farkas MD, PhD Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaSearch for more papers by this authorSasa Kadivec PhD, Sasa Kadivec PhD University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, SloveniaSearch for more papers by this authorIvan Ilic MD, Ivan Ilic MD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorAleksandar N. Neskovic MD, PhD, Aleksandar N. Neskovic MD, PhD Faculty of Medicine, University of Belgrade, Clinical Hospital Center Zemun, Department of Cardiology, Belgrade, SerbiaSearch for more papers by this authorMitja Lainscak MD, PhD, Corresponding Author Mitja Lainscak MD, PhD mitja.lainscak@guest.arnes.si Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Department of Cardiology, General Hospital Celje, Celje, SloveniaCorrespondence to: M. LainscakSearch for more papers by this author First published: 02 December 2016 https://doi.org/10.1002/jcu.22433Citations: 1 A.N.N. is partly supported by grant No. 175099 of the Ministry of Science, Republic of Serbia. For all other authors, there is nothing to declare. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat ABSTRACT Background We aimed to assess the relationship between echocardiographic characteristics and mortality in patients with chronic obstructive pulmonary disease (COPD). Methods We prospectively studied 154 patients (mean age 71 ± 10 years, 71% male) with COPD. All patients underwent transthoracic Doppler echocardiography within 48 hours of hospital admission. Primary endpoint was all-cause mortality during a median period of 22 months. Results Mildly elevated tricuspid regurgitation pressure and mitral E/e′ ratio were the most commonly encountered echocardiographic abnormalities, observed in 60% and 56% of patients, respectively. In Kaplan-Meier analysis of survival, left atrial enlargement, E/e′ ratio > 8, right atrial enlargement, right ventricular dilation, decreased tricuspid annular plane systolic excursion, decreased tricuspid annular systolic velocity, and elevated tricuspid regurgitation velocity were associated with all-cause mortality (p < 0.05 for all). In the Cox proportional hazards analysis, the mitral E/e′ ratio (hazard ratio 1.048; 95% confidence interval 1.001–1.096) remained an independent echocardiographic predictor of survival after adjustment for age, COPD severity, and other baseline echocardiographic parameters. Conclusions Among patients with COPD, an abnormal mitral E/e′ ratio was an independent echocardiographic predictor of all-cause mortality. Echocardiographic evaluation of structural and functional cardiac abnormalities provides important prognostic information and should be used routinely in the assessment of patients with COPD. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:211–221, 2017; Citing Literature Volume45, Issue4May 2017Pages 211-221 RelatedInformation
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