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Clinicopathologic factors associated with PET/CT results in early breast cancer.

2011; Lippincott Williams & Wilkins; Volume: 29; Issue: 15_suppl Linguagem: Inglês

10.1200/jco.2011.29.15_suppl.e11580

1527-7755

Cristina Maria Noblia, Carlos Cresta, M.A. González Castro, M. Eugenia Azar, Estrella García González, Eduardo Armanasco, Diana Montoya, J. M. Ipiña, Gabriel Bruno, Carlos A. González, A. Álvarez, Yamila Blumenkrantz, Márcia de Figueiredo Pereira,

Cancer Diagnosis and Treatment

e11580 Background: Increasing data support the questionable role for 18-FDG PET/CT scan in early BC assessment. We evaluated prospectively, the impact of the main clinicopathological factors of early breast cancer on (18) fluorodeoxyglucose (FDG) uptake in the breast. Methods: 60 stage 1 (n:38) and stage 2 (n:22) BC.Of these, 16 were pre-menopausal and 44 peri-menopausal.Median age was 59 yr (range, 37-83). Mean tumor size: 18.95± 9.97 mm (range, 5-40).18-FDG PET/CT took place 15 days before surgery. Results: Forty-four (72.3%) were PET/CT positive (PP) and 16 (27.7%) were PET/CT negative ( PN). Significant association between PET/CT results and clinicopathologic factors were observed for: Tumor size: 19 (32%) ≤ 10mm (T1a and T1b) (10PP and 9 PN, median SUV 1.7); 20 (33%) 10.1-20 mm (T1c) (14PP and 6 PN, median SUV 3) and 21 (35%) 20.1 -50 mm( T2) (20 PP and 1 PN;median SUV 5.6)(p= 0.009) and histologic subtype: 44 (80%) invasive ductal carcinoma (39 PP and 9 PN; median SUV 3.4), 6 (10%) invasive lobular carcinoma (3 PP and 3 PN; median SUV 2.1) and 6 (10%) other subtypes (2PP and 4 PN; median SUV 1.7) (p= 0.017). Menopausal status,age,sentinel node macro or micrometastases,nuclear grade, histologic grade and mitotic index were not significantly correlated with PET results. Multivariate logistic regresion demonstrated that small tumor size and non invasive ductal carcinoma histologic subtype were independently associated with PN results [OR: 3.13, 95%CI:1.21-8.08 (p=0.007) and OR: 3.57, 95%CI:1.40-9.10 (p=0.018), respectively]. Conclusions: Our data encourages the need to be cautious with interpretation of 18-FDG PET/CT negative results in early breast cancer population. There is a need for improving PET/CT scan accuracy, specially for non-ductal invasive carcinomas and small tumors whom are at high risk of having a PN result.