Produção Nacional
Latent tuberculosis infection screening in juvenile idiopathic arthritis patients preceding anti-TNF therapy in a tuberculosis high-risk country
2016; Elsevier BV; Volume: 57; Issue: 5 Linguagem: Inglês
10.1016/j.rbre.2016.11.004
ISSN2255-5021
AutoresJuliana Barbosa Brunelli, Karina Rossi Bonfiglioli, Clóvis A. Silva, Kátia Tomie Kozu, Cláudia Goldenstein‐Schainberg, Eloísa Bonfá, Nádia Emi Aikawa,
Tópico(s)Infectious Diseases and Tuberculosis
ResumoTo evaluate, in an endemic country, the long-term efficacy of latent tuberculosis infection (LTBI) screening and primary prophylaxis in patients with JIA receiving TNF blockers.This was a retrospective cohort that included JIA patients eligible to anti-TNF therapy. Patients were screened for LTBI prior to anti-TNF using tuberculin skin test (TST), chest X-ray and history of exposure to TB. Subjects were regularly followed at 2-month intervals.Sixty-nine JIA patients with current age of 17.4±5.8 years, mean disease duration of 5.0±4.9 years were included. Forty-seven patients received a single anti-TNF, while 22 patients switched to another anti-TNF once or twice: 57 were treated with etanercepte, 33 patients with adalimumab and 3 infliximab. LTBI screening was positive in three patients: one had TST-positive and history of TB exposure and two had solely TST-positive. No active TB was diagnosed during the study period (median of follow-up was 3.8 years).Long-term evaluation revealed that LTBI screening and primary prophylaxis before anti-TNF treatment was effective in a high-risk country and TST was the most sensitive parameter to identify these patients.
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