Early Oncologic Failure after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium
2016; Lippincott Williams & Wilkins; Volume: 197; Issue: 6 Linguagem: Inglês
10.1016/j.juro.2016.12.048
ISSN1527-3792
AutoresAhmed A. Hussein, Matthias Saar, Paul May, Carl Wijburg, Lee Richstone, Andrew A. Wagner, Timothy G. Wilson, Bertram Yuh, Joan Palou Redorta, Prokar Dasgupta, Muhammad Shamim Khan, Mani Menon, James O. Peabody, Abolfazl Hosseini, Franco Gaboardi, Alexandre Mottrie, Koon Ho Rha, Ashok K. Hemal, Michael Stöckle, John D. Kelly, Thomas J. Maatman, Abdullah Erdem Canda, Peter Wiklund, Khurshid A. Guru,
Tópico(s)Urinary and Genital Oncology Studies
ResumoNo AccessJournal of UrologyAdult Urology1 Jun 2017Early Oncologic Failure after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium Ahmed A. Hussein, Matthias Saar, Paul R. May, Carl J. Wijburg, Lee Richstone, Andrew Wagner, Timothy Wilson, Bertram Yuh, Joan Palou Redorta, Prokar Dasgupta, Mohammad Shamim Khan, Mani Menon, James O. Peabody, Abolfazl Hosseini, Franco Gaboardi, Alexandre Mottrie, Koon-ho Rha, Ashok Hemal, Michael Stockle, John Kelly, Thomas J. Maatman, Abdullah Erdem Canda, Peter Wiklund, Khurshid A. Guru, and Collaborators Ahmed A. HusseinAhmed A. Hussein Roswell Park Cancer Institute, Buffalo, New York Cairo University, Cairo, Egypt , Matthias SaarMatthias Saar University of the Saarland, Homburg, Germany , Paul R. MayPaul R. May Roswell Park Cancer Institute, Buffalo, New York , Carl J. WijburgCarl J. Wijburg Rijnstate Hospital, Arnhem, the Netherlands , Lee RichstoneLee Richstone Arthur Smith Institute for Urology, New York, New York , Andrew WagnerAndrew Wagner Beth Israel Deaconess Medical Center, Boston, Massachusetts , Timothy WilsonTimothy Wilson City of Hope and Beckman Research Institute, Duarte, California , Bertram YuhBertram Yuh City of Hope and Beckman Research Institute, Duarte, California , Joan Palou RedortaJoan Palou Redorta Fundació Puigvert, Barcelona, Spain , Prokar DasguptaProkar Dasgupta Guy's Hospital and King's College, London School of Medicine, London, United Kingdom , Mohammad Shamim KhanMohammad Shamim Khan Guy's Hospital and King's College, London School of Medicine, London, United Kingdom , Mani MenonMani Menon Henry Ford Health System, Detroit, Michigan , James O. PeabodyJames O. Peabody Henry Ford Health System, Detroit, Michigan , Abolfazl HosseiniAbolfazl Hosseini Karolinska University Hospital, Stockholm, Sweden , Franco GaboardiFranco Gaboardi Luigi Sacco University Hospital, Milan, Italy , Alexandre MottrieAlexandre Mottrie Onze-Lieve-Vrouw Ziekenhuis, Aalast, Belgium , Koon-ho RhaKoon-ho Rha Yonsei University Health System Severance Hospital, Seoul, Korea , Ashok HemalAshok Hemal Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina , Michael StockleMichael Stockle University of the Saarland, Homburg, Germany , John KellyJohn Kelly Division of Surgery and Interventional Science, Department of Urology, University College London, London, United Kingdom , Thomas J. MaatmanThomas J. Maatman Michigan Urological Clinic, Grand Rapids, Michigan , Abdullah Erdem CandaAbdullah Erdem Canda Yildirim Beyazit University, School of Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey , Peter WiklundPeter Wiklund Karolinska University Hospital, Stockholm, Sweden , Khurshid A. GuruKhurshid A. Guru Roswell Park Cancer Institute, Buffalo, New York , and Collaborators View All Author Informationhttps://doi.org/10.1016/j.juro.2016.12.048AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We sought to investigate the prevalence and variables associated with early oncologic failure. Materials and Methods: We retrospectively reviewed the IRCC (International Radical Cystectomy Consortium) database of patients who underwent robot-assisted radical cystectomy since 2003. The final cohort comprised a total of 1,894 patients from 23 institutions in 11 countries. Early oncologic failure was defined as any disease relapse within 3 months of robot-assisted radical cystectomy. All institutions were surveyed for the pneumoperitoneum pressure used, breach of oncologic surgical principles, and techniques of specimen and lymph node removal. A multivariate model was fit to evaluate predictors of early oncologic failure. The Kaplan-Meier method was applied to depict disease specific and overall survival, and Cox proportional regression analysis was used to evaluate predictors of disease specific and overall survival. Results: A total of 305 patients (22%) experienced disease relapse, which was distant in 220 (16%), local recurrence in 154 (11%), peritoneal carcinomatosis in 17 (1%) and port site recurrence in 5 (0.4%). Early oncologic failure developed in 71 patients (5%) at a total of 10 institutions. The incidence of early oncologic failure decreased from 10% in 2006 to 6% in 2015. On multivariate analysis the presence of any complication (OR 2.87, 95% CI 1.38–5.96, p = 0.004), pT3 or greater disease (OR 3.73, 95% CI 2.00–6.97, p <0.001) and nodal involvement (OR 2.14, 95% CI 1.21–3.80, p = 0.008) was a significant predictor of early oncologic failure. Patients with early oncologic failure demonstrated worse disease specific and overall survival (23% and 13%, respectively) at 1 and 3 years compared to patients who experienced later or no recurrences (log rank p <0.001). Conclusions: The incidence of early oncologic failure following robot-assisted radical cystectomy has decreased with time. Disease related rather than technical related factors have a major role in early oncologic failure after robot-assisted radical cystectomy. References 1 : Long-term oncologic outcomes following robot-assisted radical cystectomy: results from the International Robotic Cystectomy Consortium. Eur Urol2015; 68: 721. 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Google Scholar © 2017 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byElsayed A, Gibson S, Jing Z, Wijburg C, Wagner A, Mottrie A, Dasgupta P, Peabody J, Hussein A and Guru K (2020) Rates and Patterns of Recurrences and Survival Outcomes after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy ConsortiumJournal of Urology, VOL. 205, NO. 2, (407-413), Online publication date: 1-Feb-2021.Hussein A, Elsayed A, Aldhaam N, Jing Z, Osei J, Kaouk J, Redorta J, Menon M, Peabody J, Dasgupta P, Khan M, Mottrie A, Stöckle M, Hemal A, Richstone L, Hosseini A, Wiklund P, Schanne F, Kim E, Ho Rha K and Guru K (2019) Ten-Year Oncologic Outcomes Following Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy ConsortiumJournal of Urology, VOL. 202, NO. 5, (927-935), Online publication date: 1-Nov-2019.Chang S (2019) Re: Characterization of Late Recurrence after Radical Cystectomy in a Large Multicenter Cohort of Bladder Cancer PatientsJournal of Urology, VOL. 202, NO. 2, (209-209), Online publication date: 1-Aug-2019.Wei L, Hussein A, Ma Y, Azabdaftari G, Ahmed Y, Wong L, Hu Q, Luo W, Cranwell V, Bunch B, Kozlowski J, Singh P, Glenn S, Smith G, Johnson C, Liu S and Guru K (2019) Accurate Quantification of Residual Cancer Cells in Pelvic Washing Reveals Association with Cancer Recurrence Following Robot-Assisted Radical CystectomyJournal of Urology, VOL. 201, NO. 6, (1105-1114), Online publication date: 1-Jun-2019.Hussein A, May P, Jing Z, Ahmed Y, Wijburg C, Canda A, Dasgupta P, Shamim Khan M, Menon M, Peabody J, Hosseini A, Kelly J, Mottrie A, Kaouk J, Hemal A, Wiklund P and Guru K (2017) Outcomes of Intracorporeal Urinary Diversion after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy ConsortiumJournal of Urology, VOL. 199, NO. 5, (1302-1311), Online publication date: 1-May-2018.Lawrentschuk N (2017) Editorial CommentJournal of Urology, VOL. 198, NO. 3, (573-574), Online publication date: 1-Sep-2017.Smith J (2017) This Month in Adult UrologyJournal of Urology, VOL. 197, NO. 6, (1371-1372), Online publication date: 1-Jun-2017. Volume 197Issue 6June 2017Page: 1427-1436 Advertisement Copyright & Permissions© 2017 by American Urological Association Education and Research, Inc.Keywordsneoplasm recurrencetreatment failurecystectomylocalurinary bladder neoplasmsrobotic surgical proceduresAcknowledgmentsCollaborators: Mevlana Derya Balbay, School of Medicine, Yildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Ankara, Turkey; Vassilis Poulakis, Doctor's Hospital of Athens, Athens, Greece; Michael Woods, Loyola University Medical Center, Hines, Illinois; Wei Shen Tan, Division of Surgery and Interventional Science, Department of Urology, University College of London and Omar Kawa, Guy's Hospital and King's College London School of Medicine, London, United Kingdom; Giovannalberto Pini, Luigi Sacco University Hospital, Milan, Italy; and Ketan Badani, Columbia University Medical Center, New York and Youssef E. Ahmed, Roswell Park Cancer Institute, Buffalo, New York.MetricsAuthor Information Ahmed A. Hussein Roswell Park Cancer Institute, Buffalo, New York Cairo University, Cairo, Egypt More articles by this author Matthias Saar University of the Saarland, Homburg, Germany More articles by this author Paul R. May Roswell Park Cancer Institute, Buffalo, New York More articles by this author Carl J. Wijburg Rijnstate Hospital, Arnhem, the Netherlands Financial and/or other relationship with Intuitive Surgical. More articles by this author Lee Richstone Arthur Smith Institute for Urology, New York, New York More articles by this author Andrew Wagner Beth Israel Deaconess Medical Center, Boston, Massachusetts More articles by this author Timothy Wilson City of Hope and Beckman Research Institute, Duarte, California More articles by this author Bertram Yuh City of Hope and Beckman Research Institute, Duarte, California More articles by this author Joan Palou Redorta Fundació Puigvert, Barcelona, Spain More articles by this author Prokar Dasgupta Guy's Hospital and King's College, London School of Medicine, London, United Kingdom More articles by this author Mohammad Shamim Khan Guy's Hospital and King's College, London School of Medicine, London, United Kingdom More articles by this author Mani Menon Henry Ford Health System, Detroit, Michigan More articles by this author James O. Peabody Henry Ford Health System, Detroit, Michigan More articles by this author Abolfazl Hosseini Karolinska University Hospital, Stockholm, Sweden More articles by this author Franco Gaboardi Luigi Sacco University Hospital, Milan, Italy More articles by this author Alexandre Mottrie Onze-Lieve-Vrouw Ziekenhuis, Aalast, Belgium Financial and/or other relationship with Intuitive Surgical. More articles by this author Koon-ho Rha Yonsei University Health System Severance Hospital, Seoul, Korea More articles by this author Ashok Hemal Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina More articles by this author Michael Stockle University of the Saarland, Homburg, Germany More articles by this author John Kelly Division of Surgery and Interventional Science, Department of Urology, University College London, London, United Kingdom More articles by this author Thomas J. Maatman Michigan Urological Clinic, Grand Rapids, Michigan More articles by this author Abdullah Erdem Canda Yildirim Beyazit University, School of Medicine, Ankara Ataturk Training and Research Hospital, Ankara, Turkey More articles by this author Peter Wiklund Karolinska University Hospital, Stockholm, Sweden More articles by this author Khurshid A. Guru Roswell Park Cancer Institute, Buffalo, New York More articles by this author Collaborators More articles by this author Expand All Advertisement PDF downloadLoading ...
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