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BIBTEX RIS

Bacupari peel extracts ( Garcinia brasiliensis ) reduce high-fat diet-induced obesity in rats

2016; Elsevier BV; Volume: 29; Linguagem: Inglês

10.1016/j.jff.2016.11.001

2214-9414

Maria Eliza de Castro Moreira, Dorina Isabel Gomes Natal, Renata Celi Lopes Toledo, Nicolás Rosillo Ramírez, Sônia Machado Rocha Ribeiro, Laércio dos Anjos Benjamin, Leandro Licursi de Oliveira, Dayana Alves Rodrigues, Jacinto Demuner Antônio, Márcia Paranho Veloso, Marcelo Henrique dos Santos, Hércia Stampini Duarte Martino,

Natural Antidiabetic Agents Studies

The aim of this study was to determine the effect of ethanol extract of bacupari peel (EEB) on the adiposity and inflammation modulation in obese Wistar rats. The group treated with high fat diet plus EEB (BHFD) presented weight gain, visceral fat, and lee, and an adiposity index similar to the negative control group (AIN-93M). Also, the BHFD group showed antioxidant and anti-inflammatory effect, increase of peroxisome proliferator activated receptor-γ (PPAR-γ) and Interleukin-10 (IL-10) expression, and decreasing expression of lipoprotein lipase (LPL) and fatty acid synthase (FAS), and reduced the tumor necrosis factor-α (TNF-α), blood levels of glucose, alanine aminotransferase, and adipocyte hypertrophy. The molecular docking showed that morelloflavone and 7-epiclusianone compounds from bacupari extract interacted with PPAR-γ receptor, hydrophobic interaction, indicating an agonist activity of these compounds. Thus, we demonstrated that extract of bacupari presented anti-obesity activities.