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BIBTEX RIS

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer

2016; Oxford University Press; Volume: 109; Issue: 5 Linguagem: Inglês

10.1093/jnci/djw272

ISSN

1460-2105

Autores

Julien Taı̈eb, Karine Le Malicot, Qian Shi, Frédérique Penault-Llorca, Olivier Bouché, Josep Tabernero, Enrico Mini, Richard M. Goldberg, Gunnar Folprecht, Jean‐Luc Van Laethem, Daniel J. Sargent, Steven R. Alberts, Jean‐François Emile, Pierre Laurent‐Puig, Frank A. Sinicrope,

Tópico(s)

Colorectal Cancer Surgical Treatments

Resumo

The prognostic value of BRAF and KRAS mutations within microsatellite-unstable (MSI) and microsatellite-stable (MSS) subgroups of resected colon carcinoma patients remains controversial. We examined this question in prospectively collected biospecimens from stage III colon cancer with separate analysis of MSI and MSS tumors from patients receiving adjuvant FOLFOX +/- cetuximab in two adjuvant therapy trials.

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