Produção Nacional
Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
2016; Elsevier BV; Volume: 39; Issue: 2 Linguagem: Inglês
10.1016/j.bjhh.2016.09.014
ISSN1806-0870
AutoresTayse Silva dos Santos, Renato Tavares Daher, Danielle Leão Cordeiro de Farias,
Tópico(s)Viral-associated cancers and disorders
ResumoSplenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin's lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course. As a rare disease, with no randomized prospective trials, there is no standard of care for SMZL so far. Splenectomy has been done for many years as an attempt to control disease, but nowadays it has not been encouraged as first line because of new advances in therapy as rituximab, that are as effective with minimal toxicity. Facing these controversies, this review highlights advances in the literature regarding diagnosis, prognostic factors, treatment indications and therapeutic options.
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