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Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes

2016; Elsevier BV; Volume: 103; Linguagem: Inglês

10.1016/j.micpath.2016.12.006

1096-1208

Janice Luehring Giongo, Rodrigo de Almeida Vaucher, Aleksandro S. Da Silva, Camila Belmonte Oliveira, Cristiane Bastos de Mattos, Matheus D. Baldissera, Michele Rorato Sagrillo, Sílvia González Monteiro, Dayana Lacerda Custódio, Marcielly Souza de Matos, Paulo de Tarso Barbosa Sampaio, Hélder Ferreira Teixeira, L. Koester, Valdir Florêncio da Veiga,

Insect Pest Control Strategies

Aniba canelilla (H.B.K.) Mez, popularly known as "casca-preciosa" (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi.