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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Chemical constituents and antileukemic activity of Eugenia dysenterica

2016; Taylor & Francis; Volume: 31; Issue: 16 Linguagem: Inglês

10.1080/14786419.2016.1261343

ISSN

1478-6427

Autores

Renan Vitek, Leice Milla Ribeiro de Novais, Heron Fernandes Vieira Torquato, Edgar Julian Paredes‐Gamero, Mário Geraldo de Carvalho, Paulo Teixeira de Sousa, Marcos J. Jacinto, Virgínia Cláudia da Silva,

Tópico(s)

Traditional and Medicinal Uses of Annonaceae

Resumo

The study about Eugenia dysenterica led to the isolation of 3-acetyl-urs-12-en-28-oic (1), 3-acetyl-olean-12-en-28-oic acid (2) and isoquercetin (3) from the stem barks, and of 3-O-β-glucopyranosyl-β-sitosterol (4), methyl 3-hydroxy-4-methoxybenzoate (5), methyl 4-hydroxyphenyl propionate (6), E-methyl-4-hydroxycinnamate (7), quercetin-3-O-(6ꞌꞌ-O-galloyl)-β-d-glucopyranoside (8) and quercetin-3-O-β-d-galactopyranoside (9) from the leaves. The structures 1-9 were set through the analysis of their NMR spectroscopic data. Compounds 2, 3 and 5-8 were reported for the first time in the Eugenia genus. Compound 8 reduced cell viability and presented IC50 values 40.3 and 36.7 μM, for the CCRF-CEM and the Kasumi-1 cells, respectively.

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