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Vascular endothelial growth factor gene polymorphisms and the risk of renal cell carcinoma: Evidence from eight case-control studies

2016; Impact Journals LLC; Volume: 8; Issue: 5 Linguagem: Inglês

10.18632/oncotarget.14263

1949-2553

Mancheng Gong, Wenjing Dong, Zhirong Shi, Shaopeng Qiu, Runqiang Yuan,

Angiogenesis and VEGF in Cancer

// Mancheng Gong 1 , Wenjing Dong 2 , Zhirong Shi 3 , Shaopeng Qiu 4 , Runqiang Yuan 1 1 Department of Urology, Zhongshan Affiliated Hospital of Sun Yat-sen University, Zhongshan, Guangdong 528403, China 2 Department of Oncology, Zhongshan Affiliated Hospital of Sun Yat-sen University, Zhongshan, Guangdong 528403, China 3 Department of Pharmacy, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong 519020, China 4 Department of Urology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510080, China Correspondence to: Runqiang Yuan, email: yuanrunqiang2013@163.com Keywords: vascular endothelial growth factor, VEGF, renal cell carcinoma, gene polymorphism, meta-analysis Received: August 20, 2016 Accepted: December 01, 2016 Published: December 27, 2016 ABSTRACT Background: Vascular endothelial growth factor (VEGF) protein plays important role in renal cell carcinoma (RCC) development and progression. VEGF gene polymorphisms can alter the protein concentrations and might be associated with renal cell carcinoma risk. However, the results of studies investigating the association between VEGF polymorphisms and renal cell carcinoma risk are inconsistent. Thus, a meta-analysis was performed. Methods: We selected eligible studies via electronic searches. Only high-quality studies were included based on specific inclusion criteria and the Newcastle-Ottawa Scale (NOS). Results: Eight studies primarily focusing on seven polymorphisms were included in our meta-analysis. Our results showed dramatically high risks for renal cell carcinoma were found regarding most genetic models and alleles of the +936C/T polymorphism (except CT vs. CC). In addition, significant increased renal cell carcinoma risks were found regarding all genetic models and alleles of the -2578C/A polymorphism. However, no significant associations were found between renal cell carcinoma risk and the +1612G/A, -460T/C, -634G/C, -405G/C or -1154G/A polymorphisms. Conclusions: Our meta-analysis indicates that the +936C/T and -2578C/A polymorphisms of VEGF are associated with an increased risk for renal cell carcinoma. Additional rigorous analytical studies are needed to confirm our results.