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Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

2016; Elsevier BV; Volume: 27; Issue: 5 Linguagem: Inglês

10.1016/j.numecd.2016.12.003

1590-3729

Esther M. González‐Gil, Javier Santabárbara, Jonatan R. Ruiz, Silvia Bel‐Serrat, Inge Huybrechts, Raquel Pedrero‐Chamizo, Alejandro De‐la‐O, F. Gottrand, Anthony Kafatos, K. Widhalm, Yannis Μanios, Dénes Molnár, Stefaan De Henauw, María Plada, Marika Ferrari, G. Palacios Le Blé, Alfonso Siani, Marcela González‐Gross, Sonia Gómez‐Martínez, Ascensión Marcos, Luís A. Moreno, Luís A. Moreno, F. Gottrand, Stefaan De Henauw, Marcela González‐Gross, Chantal Gilbert, A. Kafatos, Christian Libersa, S Castello, Mathilde Kersting, Michael Sjöstróm, Dénes Molnár, Jean Dallongeville, Gunnar Hall, Leen Maes, Luca Scalfi, P. Meléndez, Jesús Fleta, José A. Casajús, Gerardo Rodrı́guez, Concepción Tomás, M.I. Mesana, Germán Vicente‐Rodríguez, Adoración Villarroya, Carlos Martínez Gil, Ignacio Ara, J.F. Alvira, Gloria Bueno, A. Lázaro, O. Bueno, J.F. León, J. M. Garagorri, Manuel Bueno Sánchez, Idoia Labayen, Iris Iglesia, Silvia Bel Serrat, Luis Gracia‐Marco, Theodora Mouratidou, Alba M. Santaliestra-Pasías, Esther M. González‐Gil, Pilar De Miguel‐Etayo, Cristina Julián, María L. Miguel‐Berges, Isabel Iguacel, Ascensión Marcos, Julia Wärnberǵ, Esther Nova, Sonia Gómez, L. E. Díaz, Javier Romeo, Ana M. Veses, Belén Zapatera, T. Pozo, David Martínez, Laurent Béghin, F. Gottrand, Cătălina Iliescu Gheorghiu, J. Von Berlepsch, Wolfgang Sichert‐Hellert, E. Koeppen, Dénes Molnár, Éva Erhardt, Katalin Csernus, Katalin Török, Szilvia Bokor, Angster, Enikő Nagy, Orsolya Kovács, J. Répasi, C. Codrington, María Plada, Angeliki Papadaki, Katerina Sarri, A. Viskadourou, C. Hatzis, Michael Kiriakakis, G. Tsibinos, Constantine Vardavas, M. Sbokos, E. Protoyeraki, Maria Fasoulaki, Peter Stehle, Klaus Pietrzik, C. Breidenassel, André Spinneker, J Al-Tahan, Miriam Segoviano, A. Berchtold, C. Bierschbach, E. Blatzheim, A. Schuch, P. Pickert, Manuel J. Castillo, Ángel Gutiérrez, Francisco B. Ortega, Jonatan R. Ruiz, Enrique G. Artero, V. España, David Jiménez‐Pavón, Palma Chillón, Cristóbal Sánchez‐Muñoz, M. Cuenca, D. Arcella, Elena Azzini, E. Barrison, Noemi Bevilacqua, Pasquale Buonocore, Giovina Catasta, Laura Censi, Donatella Ciarapica, P. D'Acapito, Marika Ferrari, Myriam Galfo, Cinzia Le Donne, Céline C. Leclercq, G. Maiani, Mauro Virgílio Gomes de Barros, Lorenza Mistura, A. Pasquali, Raffaela Piccinelli, A. Polito, Romana Roccaldo, Raffaella Spada, Stefania Sette, M. Zaccaria, Paola Vitaglione, Concetta Montagnese, Ilse De Bourdeaudhuij, Tineke De Vriendt, Christophe Matthys, Carine Vereecken, Mieke De Maeyer, Charlene Ottevaere, Inge Huybrechts, K. Widhalm, Katharina Phillipp, Sabine Dietrich, Yannis Μanios, Evangelia Grammatikaki, Z. Bouloubasi, Tina Louisa Cook, S. Eleutheriou, O. Consta, George Moschonis, Ioanna Katsaroli, G. Kraniou, Στάλω Παπούτσου, D. Keke, Ioanna Petraki, Elena Bellou, Sofia Tanagra, K. Kallianoti, Dionysia Argyropoulou, Stamatoula Tsikrika, Christos Karaiskos, Aline Meirhaeghe, Francisco B. Ortega, María Hagströmer, Anita Hurtig Wennlöf, Lena Hällström, E. Patterson, Lydia Kwak, Nico Rizzo, J. Sánchez-Molero, E. Picó, María Á. Navarro, Blanca Viadel, J.E. Carreres, G. Merino, R. Sanjuán, M. Lorente, María‐José Sánchez, Sarah A. Thomas, E. Allchurch, P. Burgess, Annika Åström, A. Sverkén, A. Broberg, A. Masson, Claire Lehoux, Paige Brabant, P. Pate, L. Fontaine, A. Sebok, Tünde Kuti, Adrienn Hegyi, Cristina A. Maldonado, Ana Llorente, Emilio García García, H. von Fircks, Marianne Lilja Hallberg, Maria Messerer, Mats Larsson, Helena Fredriksson, Viola Adamsson, I. Börjesson, L. Fernández, Laura Smillie, J. Wills, Raquel Pedrero‐Chamizo, A. Mélendez, Jara Valtueña, Ulrike Albers, Pedro J. Benito, J.J. Gómez Lorente, D. Cañada, A. Urzanqui, Rosa María Torres, Paloma Navarro,

Birth, Development, and Health

Background and aims Inflammation plays a key role in atherosclerosis and this process seems to appear in childhood. The ideal cardiovascular health index (ICHI) has been inversely related to atherosclerotic plaque in adults. However, evidence regarding inflammation and ICHI in adolescents is scarce. The aim is to assess the association between ICHI and inflammation in European adolescents. Methods and results As many as 543 adolescents (251 boys and 292 girls) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional multi-center study including 9 European countries, were measured. C-reactive protein (CRP), complement factors C3 and C4, leptin and white blood cell counts were used to compute an inflammatory score. Multilevel linear models and multilevel logistic regression were used to assess the association between ICHI and inflammation controlling by covariates. Higher ICHI was associated with a lower inflammatory score, as well as with several individual components, both in boys and girls (p < 0.01). In addition, adolescents with at least 4 ideal components of the ICHI had significantly lower inflammatory score and lower levels of the study biomarkers, except CRP. Finally, the multilevel logistic regression showed that for every unit increase in the ICHI, the probability of having an inflammatory profile decreased by 28.1% in girls. Conclusion Results from this study suggest that a better ICHI is associated with a lower inflammatory profile already in adolescence. Improving these health behaviors, and health factors included in the ICHI, could play an important role in CVD prevention.