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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

2016; American Association for the Advancement of Science; Volume: 8; Issue: 369 Linguagem: Inglês

10.1126/scitranslmed.aae0348

1946-6242

Grace R. Anderson, Suzanne E. Wardell, Merve Çakır, Lorin Crawford, Jim C. Leeds, Daniel P. Nussbaum, Pallavi S. Shankar, Ryan S. Soderquist, Elizabeth M. Stein, Jennifer P. Tingley, Peter Winter, Elizabeth K. Zieser-Misenheimer, Holly M. Alley, Alexander P. Yllanes, Victoria O. Haney, Kimberly Blackwell, Shannon J. McCall, Donald P. McDonnell, Kris C. Wood,

Ubiquitin and proteasome pathways

Inhibitors of BCL-X L , combined with inhibition of the mTOR/4E-BP axis, drive regressions of PIK3CA mutant breast tumors.