Produção Nacional
Parmotrema screminiae (Parmeliaceae), a Novel Lichen Species from Brazil with Potent Antimicrobial Activity
2016; FUNDAÇÃO UNIVERSIDADE FEDERAL DE MATO GROSSO DO SUL; Volume: 8; Issue: 6 Linguagem: Inglês
10.17807/orbital.v8i6.877
ISSN1984-6428
AutoresNeli Kika Honda, Deisy Santos Freitas, Ana Camila Micheletti, Nádia Cristina Pereira Carvalho, Adriano Afonso Spielmann, Luciana da Silva Canêz,
Tópico(s)Bryophyte Studies and Records
ResumoParmotrema is a genus of major interest in the lichen flora of Mato Grosso do Sul state, Brazil, since many of its species are sources of important bioactive compounds. Parmotrema screminiae Spielmann & Canez, a novel species, is a noteworthy source of norlobaridone (a depsidone), protolichesterinic acid and atranorin (a depside). Extract composition was determined by TLC and NMR techniques ( 1 H, 13 C, and DEPT-135). The acetone extract was evaluated for antibiotic activity against Gram-negative ( Escherichia coli, ATCC 25922) and Gram-positive bacteria ( Staphylococcus aureus , ATCC 25923 and clinical strains), Enterococcus faecalis (ATCC 51299), and E. faecium (vancomycin-resistant clinical strain). Highly promising results were obtained, since the extract proved active against Gram-positive bacteria alone (MIC = 31.25 μg/mL for E. faecalis , 15.6 μg/mL for both E. faecium and clinical-strain S. aureus , and 7.8 μg/mL for standard S. aureus) . Bioautography showed norlobaridone and protolichesterinic acid to be responsible for the antibiotic activity. DOI: http://dx.doi.org/10.17807/orbital.v8i6.877
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