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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid

2016; Elsevier BV; Volume: 129; Linguagem: Inglês

10.1016/j.supflu.2016.12.012

ISSN

1872-8162

Autores

Gustavo Adolfo Valente Brandão, Graziela De Luca Canto, Antoniane Arantes de Oliveira Roque, Antônio Carlos de Souza, Marina Scopel, Cláudio Augusto Oller do Nascimento, Tiana Tasca, Camila G. Pereira, Raquel Brandt Giordani,

Tópico(s)

Chemical synthesis and alkaloids

Resumo

The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercritical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to different classical low pressure solvent extraction processes in terms of global yield, extract profile and biological activity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts were analyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. The results indicated a qualitative difference in chromatographic profile of the extracts. Finally, the results point out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFE at 300 bar/55 °C against T. vaginalis and HMVII, presenting relevant information for development of new studies about cytotoxic.

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