Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies
2016; Taylor & Francis; Volume: 35; Issue: 1 Linguagem: Inglês
10.1080/07357907.2016.1247166
ISSN1532-4192
AutoresAlessandro Allegra, Vanessa Innao, Sabina Russo, Demetrio Gerace, Andrea Alonci, Caterina Musolino,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoCurcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides an overview of the recent research conducted to overcome the problems with the bioavailability of curcumin, and of the preclinical and clinical studies that have reported success in combinatorial strategies coupling curcumin with other treatments. Research on the signaling pathways that curcumin treatment targets shows that it potently acts on major intracellular components involved in key processes such as genomic modulations, cell invasion and cell death pathways. Curcumin is a promising molecule for the prevention and treatment of cancer.
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