Portal de Periódicos da CAPES

Bicuspid aortic valve outcomes

2016; Cambridge University Press; Volume: 27; Issue: 3 Linguagem: Inglês

10.1017/s1047951116002560

1467-1107

Inês Rodrigues, Ana Agapito, Lídia de Sousa, José Alberto Oliveira, Luísa Moura Branco, A Galrinho, João Abreu, Ana Teresa Timóteo, Sílvia Aguiar Rosa, Filipa Ferreira,

Infective Endocarditis Diagnosis and Management

BackgroundBicuspid aortic valve is the most common CHD. Its association with early valvular dysfunction, endocarditis, thoracic aorta dilatation, and aortic dissection is well established.ObjectiveThe aim of this study was to assess the incidence and predictors of cardiac events in adults with bicuspid aortic valve.MethodsWe carried out a retrospective analysis of cardiac outcomes in ambulatory adults with bicuspid aortic valve followed-up in a tertiary hospital centre. Outcomes were defined as follows: interventional – intervention on the aortic valve or thoracic aorta; medical – death, aortic dissection, aortic valve endocarditis, congestive heart failure, arrhythmias, or ischaemic heart disease requiring hospital admission; and a composite end point of both. Kaplan–Meier curves were generated to determine event rates, and predictors of cardiac events were determined by multivariate analysis.ResultsA total of 227 patients were followed-up over 13±9 years; 29% of patients developed severe aortic valve dysfunction and 12.3% reached ascending thoracic aorta dimensions above 45 mm. At least one cardiac outcome occurred in 38.8% of patients, with an incidence rate at 20 years of follow-up of 47±4%; 33% of patients were submitted to an aortic valve or thoracic aorta intervention. Survival 20 years after diagnosis was 94±2%. Independent predictors of the composite end point were baseline moderate–severe aortic valve dysfunction (hazard ratio, 3.19; 95% confidence interval, 1.35–7.54; p<0.01) and aortic valve leaflets calcification (hazard ratio, 4.72; 95% confidence interval, 1.91–11.64; p<0.005).ConclusionsIn this study of bicuspid aortic valve, the long-term survival was excellent but with occurrence of frequent cardiovascular events. Baseline aortic valve calcification and dysfunction were the only independent predictors of events.