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Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea

2016; Elsevier BV; Volume: 129; Issue: 5 Linguagem: Inglês

10.1182/blood-2016-09-737817

1528-0020

Chi A., Liqiang Xi, Brian Cauff, Adam DeZure, Alexandra F. Freeman, Sophie Hambleton, Gary Kleiner, Timothy Ronan Leahy, Maureen J. O’Sullivan, Michelle Makiya, Gráinne M. O’Regan, Stefania Pittaluga, Julie E. Niemela, Jennifer Stoddard, Sergio D. Rosenzweig, Mark Raffeld, Amy D. Klion, Joshua D. Milner,

Eosinophilic Disorders and Syndromes

To the editor: Somatic, gain-of-function mutations in STAT3 and STAT5 have been described in leukemias and lymphomas[1][1][⇓][2][⇓][3][⇓][4][⇓][5]-[6][6] and, more recently, in CD3-CD4+ T cells from a patient with lymphocytic variant hypereosinophilic syndrome[7][7]; whereas germ line gain-