CHRONO integrates behavioral stress and epigenetic control of metabolism
2016; Informa; Volume: 49; Issue: 4 Linguagem: Inglês
10.1080/07853890.2016.1276301
ISSN1365-2060
AutoresFumiyuki Hatanaka, Toru Takumi,
Tópico(s)Light effects on plants
ResumoCircadian rhythms are a critical part of the body's homeostatic mechanisms. These rhythms repeat with a cycle-length of approximately 24 h and are generated by a transcriptional–translational feedback loop. These rhythms are critical for proper behavioral, physiological, and molecular functions. CHRONO, a novel circadian clock gene, forms a complex with other clock proteins and modulates the circadian machinery. CHRONO also interacts with histone deacetylase (HDAC) to modulate the epigenetic status of the transcriptional regulation. Chrono knockout mice display a longer period of circadian behavior and an elevated stress response. This paper reviews the molecular function of CHRONO with a focus on epigenetic regulation and speculates on the possible function of CHRONO in physiological processes.Key messagesChrono is a circadian clock gene whose transcription exhibits a robust circadian oscillation.CHRONO is a repressor of circadian transcriptional/translational feedback loops.CHRONO may function to link epigenetic control mechanisms to stress responses.
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