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Association between Pseudomonas aeruginosa positive water samples and healthcare-associated cases: nine-year study at one university hospital

2016; Elsevier BV; Volume: 96; Issue: 3 Linguagem: Inglês

10.1016/j.jhin.2016.12.007

1532-2939

Hélène Bouxom, Pierre‐Edouard Fournier, Kévin Bouiller, Didier Hocquet, Xavier Bertrand, Anaëlle Muggeo, Thomas Guillard, Frédéric Klein, Fany F. Reffuveille, Caroline François, Anamaria Babosan, Odile Bajolet, Christophe de Champs, Caroline Laborde, Serge Aho, A. Péchinot, Vincent Le Moing, Lionel Piroth, Catherine Chirouze, Panisa Treepong, Veronica N. Kos, Christophe Guyeux, Dominique Blanc, Benoı̂t Valot, Houssein Gbaguidi‐Haore, Amélie Varin, Pascal Cholley, Michelle Thouverez, Allison Muller, Anne-Marie Rogues, Muriel Péfau, S. Alfandari, R. Gauzit, C. Dumartin, Farid El Garch, Anno de Jong, Marlène Sauget, A. Lefèbvre, Catherine Quantin, Philippe Vanhems, Jean‐Christophe Lucet, G. Nuemi, Karine Astruc, P. Chavanet, Serge Aho,

Fecal contamination and water quality

Objective To study the association between the results of water samples and Pseudomonas aeruginosa healthcare-associated cases in a French university hospital. Methods Generalized Estimating Equations were used on complete case and imputed datasets. The spatial unit was the building and the time unit was the quarter. Results For the period 2004–2013, 2932 water samples were studied; 17% were positive for P. aeruginosa. A higher incidence of P. aeruginosa cases was associated with a higher proportion of positive water samples (P=0.056 in complete case analysis and P=0.031 with the imputed dataset). The association was no longer observed when haematology and intensive care units were excluded, but was significant in analyses of data concerning intensive care units alone (P<0.001). Conclusion This study suggests that water outlet contamination in hospitals can lead to an increase in healthcare-associated P. aeruginosa cases in wards dealing with susceptible patients, but does not play a significant role in other wards.