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BIBTEX RIS

Lung Cancer

2008; Massachusetts Medical Society; Volume: 359; Issue: 13 Linguagem: Inglês

10.1056/nejmra0802714

ISSN

1533-4406

Autores

Roy S. Herbst, John V. Heymach, Scott M. Lippman,

Tópico(s)

Cancer Genomics and Diagnostics

Resumo

The Molecular Origins of Cancer series continues with this review of molecular and genetic mechanisms of lung cancer. The authors review genetic susceptibility to lung cancer and four genes of importance in the evolution of the disease: EGFR, KRAS, the PI3K–Akt–mTOR complex, and TITF1. They also discuss gene profiling and protein profiling, with emphasis on the clinical value of these methods.

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