Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial
2016; AME Publishing Company; Volume: 3; Linguagem: Inglês
10.21037/sci.2016.11.09
ISSN2313-0792
AutoresNicolai Grønne Jørgensen, Shamaila Munir Ahmad, Niels Abildgaard, Per thor Straten, Inge Marie Svane, Mads Hald Andersen, Lene Meldgaard Knudsen,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoThe B-cell lymphoma-2 (Bcl-2) family of proteins play a crucial role in multiple myeloma (MM), contributing to lacking apoptosis which is a hallmark of the disease. This makes the Bcl-2 proteins interesting targets for therapeutic peptide vaccination. We report a phase I trial of therapeutic vaccination with peptides from the proteins Bcl-2, Bcl-X
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