Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy
2016; Springer Science+Business Media; Volume: 13; Issue: 2 Linguagem: Inglês
10.1007/s11306-016-1147-x
ISSN1573-3890
AutoresRalf J. M. Weber, Thomas N. Lawson, Reza M. Salek, Timothy M. D. Ebbels, Robert C. Glen, Royston Goodacre, Julian L. Griffin, Kenneth Haug, Albert Koulman, Pablo Moreno, Markus Ralser, Christoph Steinbeck, Warwick B. Dunn, Mark R. Viant,
Tópico(s)Bioinformatics and Genomic Networks
ResumoFor metabolomics to achieve its full potential in both the basic and applied sciences the accessibility, reporting, reproducibility and overall harmonisation of such computational tools and resources must be improved significantly.Only then can there be confidence that results obtained in one laboratory can be reproduced in another laboratory elsewhere across the globe.The development of standardised and reproducible computational workflows provides one route to achieving closer harmonisation.This is a logical evolution following the work of the Metabolomics Standards Initiative where one working group aimed to establish minimal reporting requirements for data processing (Goodacre et al. 2007).Galaxy is a widely used workflow platform that has helped to transform genomics research by increasing the accessibility of powerful data processing and analysis tools to non-bioinformaticians; i.e., to bench biologists (See "How to Build Bioinformatic Pipelines Using Galaxy"
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