Portal de Periódicos da CAPES

Glioblastoma on a microfluidic chip: Generating pseudopalisades and enhancing aggressiveness through blood vessel obstruction events

2016; Oxford University Press; Linguagem: Inglês

10.1093/neuonc/now230

1523-5866

José M. Ayuso, Rosa Monge, Alicia Martínez‐González, Marı́a Virumbrales-Muñoz, Guillermo Llamazares, J. Berganzo, Aurelio Hernández‐Laín, Jorge Santolaria, M. Doblaré, Christopher G. Hubert, Jeremy N. Rich, Pilar Sánchez‐Gómez, Vı́ctor M. Pérez-Garcı́a, Ignacio Ochoa, Luis J. Fernández,

Cell Image Analysis Techniques

Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions, named pseudopalisades, are characteristic in these tumors and have been hypothesized to be waves of migrating glioblastoma cells. These "waves" of cells are thought to be induced by oxygen and nutrient depletion caused by tumor-induced blood vessel occlusion. Although the universal presence of these structures in GBM tumors suggests that they may play an instrumental role in GBM's spread and invasion, the recreation of these structures in vitro has remained challenging.