Produção Nacional
Revisado por pares
Ciprofloxacin induces oxidative stress in duckweed (Lemna minor L.): Implications for energy metabolism and antibiotic-uptake ability
2017; Elsevier BV; Volume: 328; Linguagem: Inglês
10.1016/j.jhazmat.2017.01.005
ISSN1873-3336
AutoresMarcelo Pedrosa Gomes, Cíntia Almeida Gonçalves, Júlio César Moreira Brito, ANNA MARY DA SILVA SOUZA, Fernanda Vieira da Silva Cruz, Elisa Monteze Bicalho, Cléber Cunha Figueredo, Queila Souza Garcia,
Tópico(s)Coastal wetland ecosystem dynamics
ResumoWe investigate the physiological responses and antibiotic-uptake capacity of Lemna minor exposed to ciprofloxacin. Ciprofloxacin (Cipro) induced toxic effects and hormesis in plants by significantly modifying photosynthesis and respiration pathways. A toxic effect was induced by a concentration ≥1.05 mg ciprofloxacin l−1 while hormesis occurs at the lowest concentration studied (0.75 mg ciprofloxacin l−1). By impairing normal electron flow in the respiratory electron transport chain, ciprofloxacin induces hydrogen peroxide (H2O2) production. The ability of plants to cope with H2O2 accumulation using antioxidant systems resulted in stimulation/deleterious effects to photosynthesis by Cipro. Cipro-induced oxidative stress was also associated with the ability of L. minor plants to uptake the antibiotic and, therefore, with plant-uptake capacity. Our results indicate that instead of being a photosystem II binding molecule, Cipro induces oxidative stress by targeting the mitochondrial ETC, which would explain the observed effects of the antibiotic on non-target eukaryotic organisms. The selection of plants species with a high capacity to tolerate oxidative stress may constitute a strategy to be used in Cipro-remediation programs.
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