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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

2017; Elsevier BV; Volume: 140; Linguagem: Inglês

10.1016/j.antiviral.2016.12.023

ISSN

1872-9096

Autores

Silvia Ghezzi, Lynsay C. Cooper, Alicia Rubio, Isabel Pagani, Maria Rosaria Capobianchi, Giuseppe Ippolito, Julien Pelletier, Maria Cecília Zorél Meneghetti, Marcelo A. Lima, Mark A. Skidmore, Vania Broccoli, Edwin A. Yates, Elisa Vicenzi,

Tópico(s)

Viral Infections and Vectors

Resumo

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs).

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