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Brazilian Amazon Traditional Medicine and the Treatment of Difficult to Heal Leishmaniasis Wounds with Copaifera

2017; Hindawi Publishing Corporation; Volume: 2017; Issue: 1 Linguagem: Inglês

10.1155/2017/8350320

1741-4288

Kelly Cristina Oliveira de Albuquerque, Andreza do Socorro Silva da Veiga, João Victor Silva-Silva, Heliton Patrick Cordovil Brígido, Erica Patrícia dos Reis Ferreira, Erica Vanessa Souza Costa, Andrey Moacir do Rosário Marinho, Sandro Percário, Maria Fâni Dolabela,

History of Medicine and Tropical Health

The present study describes the use of the traditional species Copaifera for treating wounds, such as ulcers scarring and antileishmanial wounds. It also relates phytochemical studies, evaluation of the leishmanicidal activity, and toxicity. The species of Copaifera with a higher incidence in the Amazon region are Copaifera officinalis , Copaifera reticulata , Copaifera multijuga Hayne. The copaiba oil is used in the Amazon’s traditional medicine, especially as anti‐inflammatory ingredient, in ulcers healing, and in scarring and for leishmaniasis. Chemical studies have shown that these oils contain diterpenes and sesquiterpenes. The copaiba oil and terpenes isolated have antiparasitic activity, more promising in the amastigote form of L. amazonensis . This activity is probably related to changes in the cell membrane and mitochondria. The oil showed low cytotoxicity and genotoxicity. Furthermore, it may interfere with immune response to infection and also has a healing effect. In summary, the copaiba oil is promising as leishmanicidal agent.