Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review
2017; Multidisciplinary Digital Publishing Institute; Volume: 8; Issue: 1 Linguagem: Inglês
10.3390/genes8010043
ISSN2073-4425
AutoresSílvia A. Sousa, Joana R. Feliciano, Tiago Pita, Soraia Guerreiro, Jorge H. Leitão,
Tópico(s)Plant Pathogenic Bacteria Studies
ResumoBurkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic fibrosis and immunocompromised patients. Their eradication is very difficult due to the high level of intrinsic resistance to clinically relevant antibiotics. Bcc bacteria have large and complex genomes, composed of two to four replicons, with variable numbers of insertion sequences. The complexity of Bcc genomes confers a high genomic plasticity to these bacteria, allowing their adaptation and survival to diverse habitats, including the human host. In this work, we review results from recent studies using omics approaches to elucidate in vivo adaptive strategies and virulence gene regulation expression of Bcc bacteria when infecting the human host or subject to conditions mimicking the stressful environment of the cystic fibrosis lung.
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