Injectable electroactive hydrogels based on Pluronic® F127 and tetraaniline copolymer
2017; Elsevier BV; Volume: 88; Linguagem: Inglês
10.1016/j.eurpolymj.2017.01.013
ISSN1873-1945
AutoresE Jin, Zhen Zhang, Hua Lian, Xin Chen, Chunsheng Xiao, Xiuli Zhuang, Xuesi Chen,
Tópico(s)Advanced Sensor and Energy Harvesting Materials
ResumoNowadays, injectable electroactive hydrogels have received much attention in biomedical field. In this article, an electroactive copolymer was successfully synthesized by chemical coupling of tetraaniline (TA) onto the chain end of Pluronic® F127. The structure of the resultant copolymer was characterized by Fourier transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–vis), and 1H NMR. Cyclic voltammetry (CV) measurements of the copolymer solution indicated good electroactivity. Moreover, the electroactive copolymer showed temperature-responsive sol-gel transitions in aqueous media. Gelation properties of the hydrogels were also studied by rheometer and the results showed that the introduction of TA segment could enhance the mechanical properties of hydrogel. Based on the analyses of 13C NMR spectra and dynamic light scattering (DLS), the sol-gel transition mechanism was attributed to the dehydration of PEG chains in F127. The MTT assay revealed that the TA conjugated F127 copolymer showed excellent biocompatibility. And the copolymer could form gel in vivo at 15 min post injection. Therefore, this biocompatible copolymer acted as injectable electroactive hydrogels may have great potential in biomedical uses.
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