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Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

2017; American Chemical Society; Volume: 139; Issue: 6 Linguagem: Inglês

10.1021/jacs.6b11079

1943-2984

Vivek S. Raut, Marion Jean, Nicolas Vanthuyne, Christian Roussel, Thierry Constantieux, Cyril Bressy, Xavier Bugaut, Damien Bonne, Jean Rodriguez,

Asymmetric Synthesis and Catalysis

For the first time, enantiomerically enriched atropoisomeric furans have been accessed using a central-to-axial chirality conversion strategy. Hence, oxidation of the enantioenriched dihydrofuran precursors gave rise to axially chiral furans with high enantiopurities accounting from excellent conversion percentages (cp) in most cases.